ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2018
Genetic risk factors for pediatric-onset multiple sclerosis.
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Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29citing papers in PubMed, 1 pooled it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis.BMC neurology · 2021Pooled it
- Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions.Neurology and therapy · 2026Review
- A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data.International journal of molecular sciences · 2025Article
- Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.Neurology · 2025Article
- Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- The immunological bases of alemtuzumab as induction-therapy in pediatric-onset multiple sclerosis.Frontiers in immunology · 2024Review
- Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Alemtuzumab following natalizumab is more effective in adult-onset than paediatric-onset multiple sclerosis.Therapeutic advances in neurological disorders · 2023Article
- Aging in multiple sclerosis: from childhood to old age, etiopathogenesis, and unmet needs: a narrative review.Frontiers in neurology · 2023Review
- Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Article
- Multiple Sclerosis in Children: Differential Diagnosis, Prognosis, and Disease-Modifying Treatment.CNS drugs · 2022Review
- Comprehensive Assessment of Multiple Sclerosis: From Immunotherapy and Immunopathogenesis to Predictive Biomarkers.Iranian journal of pathology · 2022Review
- Genetics and functional genomics of multiple sclerosis.Seminars in immunopathology · 2022Review
- Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Autoimmune Disorders of the Nervous System: Pathophysiology, Clinical Features, and Therapy.Frontiers in neurology · 2021Review
- Seafood, fatty acid biosynthesis genes, and multiple sclerosis susceptibility.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Article
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Authors and funding
41 authors.
Milena A GianfrancescoDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Pernilla StridhDepartment of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Xiaorong ShaoDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Brooke RheadComputational Biology Graduate Group, University of California, Berkeley, Berkeley, CA, USA.
Jennifer S GravesDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Tanuja ChitnisPartners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, Boston, MA, USA.
Amy WaldmanDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Timothy LotzeBlue Bird Circle Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX, USA.
Teri SchreinerChildren's Hospital Colorado, University of Colorado, Denver, CO, USA.
Anita BelmanThe Lourie Center for Pediatric MS, Stony Brook Children's Hospital, Stony Brook, NY, USA.
Benjamin GreenbergDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern, Dallas, TX, USA.
Bianca Weinstock-GuttmanPediatric Multiple Sclerosis Center, Jacobs Neurological Institute, SUNY Buffalo, Buffalo, NY, USA.
Gregory AaenPediatric MS Center, Loma Linda University Children's Hospital, Loma Linda, CA, USA.
Jan M TillemaPediatric MS Center, Mayo Clinic, Rochester, MN, USA.
Janace HartDepartment of Neurology and Regional Pediatric MS Center, University of California, San Francisco, San Francisco, CA, USA.
Stacy CaillierDepartment of Neurology and Regional Pediatric MS Center, University of California, San Francisco, San Francisco, CA, USA.
Jayne NessCenter for Pediatric Onset Demyelinating Disease, University of Alabama and Children's Hospital of Alabama, Birmingham, AL, USA.
Yolanda HarrisCenter for Pediatric Onset Demyelinating Disease, University of Alabama and Children's Hospital of Alabama, Birmingham, AL, USA.
Jennifer RubinDivision of Neurology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Meghan CandeeUniversity of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.
Lauren KruppThe Lourie Center for Pediatric MS, Stony Brook Children's Hospital, Stony Brook, NY, USA.
Mark GormanBoston Children's Hospital, Boston, MA, USA.
Leslie BensonBoston Children's Hospital, Boston, MA, USA.
Moses RodriguezPediatric MS Center, Mayo Clinic, Rochester, MN, USA.
Soe MarPediatric-onset Demyelinating Diseases and Autoimmune Encephalitis Center, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
Ilana KahnChildren's National Medical Center, Washington, DC, USA.
John RoseDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Shelly RoalstadDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
T Charles CasperDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Ling ShenDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Hong QuachDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Diana QuachDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Jan HillertInstitute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden.
Anna HedstromInstitute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden.
Tomas OlssonDepartment of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Ingrid KockumDepartment of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Lars AlfredssonInstitute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden/Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
Catherine SchaeferDivision of Research, Kaiser Permanente, Oakland, CA, USA/Research Program on Genes, Environment and Health, Kaiser Permanente, Oakland, CA.
Lisa F BarcellosDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA/Computational Biology Graduate Group, University of California, Berkeley, Berkeley, CA, USA; Division of Research, Kaiser Permanente, Oakland, CA, USA.
Emmanuelle WaubantDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Network of Pediatric Multiple Sclerosis Centers
Funding
A Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8MGENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5MThe Identification of Risk Factors for the Complex MS PhenotypeR01AI076544 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2008 to 2012
$3.6MNovel Strategies to Identify GxE Contributions to MS PathogenesisR01ES017080 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2011 to 2015
$3.0MEnvironmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8MGenetic and non-genetic risk factors in MSR01NS049510 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2005 to 2009
$2.7MDevelopment of visual and neurologic outcome measures in pediatric MSK23NS069806 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WALDMAN, AMY TARA · 2012 to 2016
$924kEstablishing the Causal Role of Low Vitamin D in Multiple SclerosisF31NS096885 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RHEAD, BROOKE · 2016 to 2019
$125kDirect and indirect effects of obesity genes on multiple sclerosisF31NS093832 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GIANFRANCESCO, MILENA ANNE · 2015 to 2015
$37kNHGRI NIH HHS T32 HG000047NIAID NIH HHS R01 AI076544NIA NIH HHS RC2 AG036607NIEHS NIH HHS R01 ES017080NINDS NIH HHS F31 NS093832NINDS NIH HHS F31 NS096885NINDS NIH HHS K23 NS069806NINDS NIH HHS R01 NS049510NINDS NIH HHS R01 NS071463
Abstract
backgroundStrong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology.
objectiveWe comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS.
methodsCases with onset <18 years (
results
conclusionPediatric and adult MS share many genetic variants suggesting similar biological processes are present. MHC variants beyond
Indexed as
FemaleGenetic Predisposition to DiseaseGenetic TestingHLA-DRB1 ChainsHumansLogistic ModelsMaleMultiple SclerosisPolymorphism, Single NucleotideRisk FactorsSwedenHLA-DRB1 ChainsepidemiologygeneticsMultiple sclerosispediatrics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.