ArticleMolecular ecology2017
Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus).
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Two Secondary Introductions From a Shared Bridgehead Population Show Evidence of Divergent and Parallel Selection.Molecular ecology · 2026Article
- Genomic signatures of population isolation in an endangered European rodent.BMC genomics · 2026Article
- Article
- Surviving the Squeeze: Genomic Analysis of a Successful Invasion by European Common Wall Lizards (Podarcis muralis) in North America (Ohio, USA).Molecular ecology · 2026Article
- Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar.Genetics, selection, evolution : GSE · 2025Article
- Population History Across Timescales in an Urban Archipelago.Genome biology and evolution · 2025Article
- Population history across timescales in an urban archipelago.bioRxiv : the preprint server for biology · 2025Article
- No detectable effect of urbanization on genetic drift or gene flow in specialist herbivorous insects of milkweed.PloS one · 2025Article
- Online toolkits for collaborative and inclusive global research in urban evolutionary ecology.Ecology and evolution · 2024Article
- Genomic signatures of climate adaptation in bank voles.Ecology and evolution · 2024Article
- The genomic response to urbanization in the damselflyEvolutionary applications · 2023Article
- Urbanization drives adaptive evolution in a Neotropical bird.Current zoology · 2023Article
- Reactive oxygen species: role in obesity and mitochondrial energy efficiency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Genetic architecture of the response ofFrontiers in plant science · 2023Article
- Linking genetic, morphological, and behavioural divergence between inland island and mainland deer mice.Heredity · 2022Article
- Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions.Ecology and evolution · 2021Article
- Replicated, urban-driven exposure to metallic trace elements in two passerines.Scientific reports · 2021Article
- Disentangling environmental drivers of circadian metabolism in desert-adapted mice.The Journal of experimental biology · 2021Article
- Mammalian body size is determined by interactions between climate, urbanization, and ecological traits.Communications biology · 2021Article
- Locally adapted gut microbiomes mediate host stress tolerance.The ISME journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Urbanization significantly alters natural ecosystems and has accelerated globally. Urban wildlife populations are often highly fragmented by human infrastructure, and isolated populations may adapt in response to local urban pressures. However, relatively few studies have identified genomic signatures of adaptation in urban animals. We used a landscape genomic approach to examine signatures of selection in urban populations of white-footed mice (Peromyscus leucopus) in New York City. We analysed 154,770 SNPs identified from transcriptome data from 48 P. leucopus individuals from three urban and three rural populations and used outlier tests to identify evidence of urban adaptation. We accounted for demography by simulating a neutral SNP data set under an inferred demographic history as a null model for outlier analysis. We also tested whether candidate genes were associated with environmental variables related to urbanization. In total, we detected 381 outlier loci and after stringent filtering, identified and annotated 19 candidate loci. Many of the candidate genes were involved in metabolic processes and have well-established roles in metabolizing lipids and carbohydrates. Our results indicate that white-footed mice in New York City are adapting at the biomolecular level to local selective pressures in urban habitats. Annotation of outlier loci suggests selection is acting on metabolic pathways in urban populations, likely related to novel diets in cities that differ from diets in less disturbed areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.