Evidence map›Paper›PMID 28980301›Full record

ArticleEuropean journal of immunology2018

Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice.

Marta Cuenca, Joan Puñet-Ortiz, Maria Ruart, Cox Terhorst, Pablo Engel

Open access · bronzeAbstract read
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Marta CuencaImmunology Unit, Department of Biomedical Sciences, University of Barcelona Medical School, Barcelona, Spain.
Joan Puñet-OrtizImmunology Unit, Department of Biomedical Sciences, University of Barcelona Medical School, Barcelona, Spain.
Maria RuartBarcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
Cox TerhorstDivision of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Pablo EngelImmunology Unit, Department of Biomedical Sciences, University of Barcelona Medical School, Barcelona, Spain.ORCID 0000-0001-8410-252X
Universitat de Barcelona · ESBeth Israel Deaconess Medical Center · USHospital Clínic de Barcelona · ES

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
The Slamf3, Slamf5, and Slamf6 receptor-induced pathways to murine lupusP01AI065687 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHARPE, ARLENE H. · 2006 to 2016
$14.7M
Enhancing immune regulation in gene therapy for hemophiliaR01HL131093 · NHLBI · UNIVERSITY OF FLORIDA · PI Ype Peter De Jong, Roland W. Herzog · 2016 to 2026
$7.2M
NIAID NIH HHS P01 AI065687NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells develop into three subsets (NKT1, NKT2, and NKT17) expressing a distinct transcription factor profile, which regulates cytokine secretion upon activation. iNKT cell development in the thymus is modulated by signaling lymphocytic activation molecule family (SLAMF) receptors. In contrast to other SLAMF members, Ly9 (SLAMF3) is a non-redundant negative regulator of iNKT cell development. Here, we show that Ly9 influences iNKT cell lineage differentiation. Ly9-deficient mice on a BALB/c background contained a significantly expanded population of thymic NKT2 cells, while NKT1 cells were nearly absent in BALB/c.Ly9

Indexed as

AnimalsCell DifferentiationLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsSignaling Lymphocytic Activation Molecule FamilySpleenThymus GlandT-Lymphocyte SubsetsLy9 protein, mouseSignaling Lymphocytic Activation Molecule FamilyCD229Inhibitory receptorsNKT2SLAM family receptors

Identifiers

PMID28980301
PMCPMC5762399
OpenAlexW2763209931

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.