ArticleJournal of assisted reproduction and genetics2018
Combined advanced parental age has an additive negative effect on live birth rates-data from 4057 first IVF/ICSI cycles.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father.Journal of assisted reproduction and genetics · 2025Article
- Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health.Antioxidants (Basel, Switzerland) · 2025Review
- Do different male infertility factors impact embryological, cumulative pregnancy and neonatal outcomes in IVF/ICSI cycles? A retrospective cohort study.Human reproduction open · 2025Article
- Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Improved The Aged Mouse IVM Oocytes Quality.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Resveratrol intake by males increased the mitochondrial DNA copy number and telomere length of blastocysts derived from aged mice.The Journal of reproduction and development · 2024Article
- Article
- Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes.Journal of clinical medicine · 2024Review
- A DNA Methylation Perspective on Infertility.Genes · 2023Review
- Male reproductive ageing: a radical road to ruin.Human reproduction (Oxford, England) · 2023Article
- The association between the number of oocytes retrieved and cumulative live birth rate in different female age strata.Scientific reports · 2023Article
- Factors influencing clinical pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection in older women.African health sciences · 2023Article
- Nomogram for Predicting Live Birth after the First Fresh Embryo Transfer in Patients with PCOS Undergoing IVF/ICSI Treatment with the GnRH-Ant Protocol.Diagnostics (Basel, Switzerland) · 2023Article
- In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.JBRA assisted reproduction · 2023Review
- The impact of paternal age on cumulative assisted reproductive technology outcomes.Frontiers in medicine · 2023Article
- Reproductive axis ageing and fertility in men.Reviews in endocrine & metabolic disorders · 2022Review
- Article
- Predicting the probability of a live birth after a freeze-all based in vitro fertilization-embryo transfer (IVF-ET) treatment strategy.Translational pediatrics · 2022Article
- Effect of intrauterine perfusion of granular leukocyte-colony stimulating factor on the outcome of frozen embryo transfer.World journal of clinical cases · 2021Article
- Improving Sperm Oxidative Stress and Embryo Quality in Advanced Paternal Age Using Idebenone In Vitro-A Proof-of-Concept Study.Antioxidants (Basel, Switzerland) · 2021Article
- Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.Reproductive biology and endocrinology : RB&E · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates.
methodsRetrospective data analysis of 4057 first cycles at a fertility centre between 2009 and 2013 was compiled. Donor, preimplantation genetic screening and double embryo transfer cycles were excluded. Main outcomes measured were clinical pregnancy, viable pregnancy, live birth and term birth.
resultsLogistic regression indicated strong negative associations for maternal ages exceeding 27 years with clinical pregnancies (p < 0.001), viable pregnancies (p < 0.001), live births (p < 0.001) and term births (p < 0.001). There was evidence of negative associations between paternal age and both viable pregnancies (p = 0.06) and live births (p = 0.04), such that the probability of pregnancy was 10% further reduced for women who were 35 years with a partner over 40 years vs. women aged 35 years with a partner under 30 years. There was evidence of an interaction between maternal age and the paternal age on term births (p = 0.02) such that advanced paternal age's effect on the probability of a term birth was only evident in couples where the maternal age ranged between ~27 and 35 years.
conclusionsThere is an additive effect to pregnancy and live birth rates when both partners are of an advanced age, thus highlighting the need for pre-conception public health messaging and a combined approach to ART counselling assessing both parental ages in combination.
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Registered trials
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