ArticleJournal of materials science. Materials in medicine2017
A 24-month evaluation of a percutaneous osseointegrated limb-skin interface in an ovine amputation model.
Article in Journal of materials science. Materials in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Enhancing skin-implant integration in lower-limb transcutaneous prostheses: From interface biology to bioactive, antimicrobial and cell-based strategies.Journal of orthopaedic translation · 2026Review
- 3D-printed peek exo-endoprosthesis for limb salvage in dogs and cats.Veterinary research communications · 2026Article
- Fluorapatite-Coated Percutaneous Osseointegrated Prostheses Limit Epidermal Downgrowth and Promote Periprosthetic Healing in a Weight-Bearing Sheep Model-A Preliminary Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Pre-clinical development of a wireless neural interface system for osseointegrated prosthetic control in sheep.Frontiers in neuroscience · 2025Article
- Comparison In Vitro Study on the Interface between Skin and Bone Cell Cultures and Microporous Titanium Samples Manufactured with 3D Printing Technology Versus Sintered Samples.Nanomaterials (Basel, Switzerland) · 2024Article
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- Electrical Stimulation of Distal Tibial Nerve During Stance Phase of Walking May Reverse Effects of Unilateral Paw Pad Anesthesia in the Cat.Motor control · 2023Article
- Fluorapatite-Coated Percutaneous Devices Promote Wound Healing and Limit Epithelial Downgrowth at the Skin-Device Interface.Journal of tissue engineering and regenerative medicine · 2023Article
- An antimicrobial blue light device to manage infection at the skin-implant interface of percutaneous osseointegrated implants.PloS one · 2023Article
- Junctional epithelium and hemidesmosomes: Tape and rivets for solving the "percutaneous device dilemma" in dental and other permanent implants.Bioactive materials · 2022Review
- Temporary Botulinum Immobilization of Residuum Muscles for Facilitation of the Initial Ingrowth of Skin to the PorousFrontiers in rehabilitation sciences · 2022Article
- Finite Element Analysis of Transhumeral and Transtibial Percutaneous Osseointegrated Endoprosthesis Implantation.Frontiers in rehabilitation sciences · 2021Article
- Recent Progress in Animal Studies of the Skin- and Bone-integrated Pylon With Deep Porosity for Bone-Anchored Limb Prosthetics With and Without Neural Interface.Military medicine · 2021Review
- Upper extremity prosthetic selection influences loading of transhumeral osseointegrated systems.PloS one · 2020Article
- Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr (Frontiers in veterinary science · 2019Article
- Variation in bone response to the placement of percutaneous osseointegrated endoprostheses: A 24-month follow-up in sheep.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Percutaneous osseointegrated (OI) prostheses directly connect an artificial limb to the residual appendicular skeleton via a permanently implanted endoprosthesis with a bridging connector that protrudes through the skin. The resulting stoma produces unique medical and biological challenges. Previously, a study using a large animal amputation model indicated that infection could be largely prevented, for at least a 12-month period, but the terminal epithelium continued to downgrow. The current study was undertaken to test the longer-term efficacy of this implant construct to maintain a stable skin-implant interface for 24 months. Using the previously successful amputation and implantation surgical procedure, a total of eight sheep were fitted with a percutaneous OI prosthesis. Two animals were removed from the study due to early complications. Of the remaining six sheep, one (16.7%) became infected at 15-months post-implantation and five remained infection-free for the intended 24 months. The histological data of the remaining animals further confirmed the grossly observable epithelial downgrowth. Albeit a receding interface, it was clear that all animals that survived to the end of the study had residual fibrous soft-tissue ingrowth into, and debris within, the exposed titanium porous-coated surface. Overall, the data demonstrated that the porous coated subdermal barrier offered initial protection against infection. However, the fibrous skin attachment was continuously lysed over time by the down-growing epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.