ArticleEnvironmental science and pollution research international2017
Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes.
Article in Environmental science and pollution research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders.Inflammopharmacology · 2025Pooled it
- Pooled it
- Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review.Advances in therapy · 2020Pooled it
- Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system.BMC pharmacology & toxicology · 2025Article
- Dietary supplements for prevention of Alzheimer's disease:Iranian journal of basic medical sciences · 2025Article
- No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum.The Journal of veterinary medical science · 2024Article
- Bupropion and varenicline administration reversed depressive behavior induced by acetamiprid exposure in mice: the role of nAChRs in depression.Toxicology research · 2024Article
- The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex.Frontiers in veterinary science · 2024Article
- Protective effect of vitamin C against thiamethoxam-induced toxicity in male rats.Open veterinary journal · 2023Article
- Screening of Toxic Effects of Neonicotinoid Insecticides with a Focus on Acetamiprid: A Review.Toxics · 2023Review
- Developmental exposure of zebrafish to neonicotinoid pesticides: Long-term effects on neurobehavioral function.Neurotoxicology · 2023Article
- Osteoconductivity and neurotoxicity of silver-containing hydroxyapatite coating cage for spinal interbody fusion in rats.JOR spine · 2023Article
- Dual Mechanism of Action of Curcumin in Experimental Models of Multiple Sclerosis.International journal of molecular sciences · 2022Article
- Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage.Archives of toxicology · 2022Review
- Ameliorative role of ascorbic acid on the oxidative stress and genotoxicity induced by acetamiprid in Nile tilapia (Oreochromis niloticus).Environmental science and pollution research international · 2021Article
- Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2021Article
- Acetamiprid-induced Cyto- and Genotoxicity in the AR42J Pancreatic Cell Line.Turkish journal of pharmaceutical sciences · 2020Article
- An Overview on the Effect of Neonicotinoid Insecticides on Mammalian Cholinergic Functions through the Activation of Neuronal Nicotinic Acetylcholine Receptors.International journal of environmental research and public health · 2020Review
- Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity.Environmental science and pollution research international · 2020Article
- Curcumin attenuates collagen-induced inflammatory response through the "gut-brain axis".Journal of neuroinflammation · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume acetamiprid (ACE); the second was an experimental group (ACE) that consumed 40 mg/kg body weight/day of acetamiprid; and the third group (CUR) received curcumin (100 mg/kg) and acetamiprid (40 mg/kg) in combination. Neurobehavioral evaluations including inclined plane performance and forepaw grip time were studied. Treatment with CUR significantly prevented ACE-treated rats from impairments in the performance of neurobehavioral tests, indicating the presence of deficits on sensorimotor and neuromuscular responses. In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium. Taken together, these results demonstrate for the first time that ACE treatment substantially impairs the survival of primary neuronal cells through the induction of necrosis concomitantly with the generation of an oxidative stress. Additionally, curcumin reduced histopathological changes caused by ACE.
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