Evidence map›Paper›PMID 28979897›Full record

ArticleFrontiers in cardiovascular medicine2017

Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System.

Tanja Zeller, Moritz Seiffert, Christian Müller, Markus Scholz, Anna Schäffer, Francisco Ojeda, Heinz Drexel, Axel Mündlein, Marcus E Kleber, Winfried März and 10 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04936438 (Clinical Cohort Study - INTERCATH), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04936438 unknown statusnot on this map

Clinical Cohort Study - INTERCATH: A Diseased Cohort Based Epidemiologic, Prospective, Single Center Cohort Study for Novel Research in Cardiovascular Risk Prediction Using a Sophisticated Biobank

Typeobservational_patient_registrySponsorUniversity of Hamburg-EppendorfRan2015 to 2025Enrolled5,000ConditionsCoronary Artery Disease, Coronary Disease, Coronary Syndrome, SCAD
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 4 countries.

Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Moritz SeiffertDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Christian MüllerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Anna SchäfferDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Francisco OjedaDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Heinz DrexelVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Axel MündleinVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Marcus E KleberMannheim Medical Faculty, 5th Department of Medicine Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Heidelberg University, Mannheim, Germany.
Winfried MärzMannheim Medical Faculty, 5th Department of Medicine Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Heidelberg University, Mannheim, Germany.
Christoph SinningDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Fabian J BrunnerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Christoph WaldeyerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Till KellerKerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.
Christoph H SaelyVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Karsten SydowDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Joachim ThieryLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Daniel TeupserLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Renate SchnabelDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
University Medical Center Hamburg-Eppendorf · DEUniversität Hamburg · DELeipzig University · DEDrexel University · USGerman Centre for Cardiovascular Research · DELandeskrankenhaus Feldkirch · ATLudwig-Maximilians-Universität München · DESynlab (Germany) · DEUniversity Hospital Heidelberg · DEVorarlberg Institute for Vascular Investigation and Treatment · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD. A two-stage approach including a discovery and a replication stage was used to assess genetic variants. In the discovery phase, a meta-analysis of genome-wide association data of 4,930 CAD-subjects assessed by the Gensini score was performed. Selected single nucleotide polymorphisms (SNPs) were replicated in 2,283 CAD-subjects by

Indexed as

geneticsgenome-wide associationGensini scorepolymorphismseverity of coronary artery disease

Identifiers

PMID28979897
PMCPMC5611399
OpenAlexW2751779728

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.