ArticleElectronic physician2017
Anxiety and depression in patients with gastroesophageal reflux disorder.
Article in Electronic physician, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Gastrointestinal Issues in Depression, Anxiety, and Neurodegenerative Diseases: A Systematic Review on Pathways and Clinical Targets Implications.CNS & neurological disorders drug targets · 2024Pooled it
- Mendelian randomization study of gastroesophageal reflux disease and major depression.PloS one · 2023Pooled it
- Approach to stress endocrine response: somatization in the context of gastroenterological symptoms: a systematic review.African health sciences · 2019Pooled it
- A multidisciplinary approach to the management of disorders of gut-brain interaction: psychopharmacology, psychotherapy, and diet.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Analyzing the correlation between gastroesophageal reflux disease and anxiety and depression based on ordered logistic regression.Scientific reports · 2024Article
- Generalized Anxiety Disorder Associated With Gastroesophageal Reflux Disease Among the Saudi Population.Cureus · 2023Article
- Depression Promotes Gastroesophageal Reflux Disease: New Evidence Based on Mendelian Randomization.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Comparison of the effects of individual symptoms of gastroesophageal reflux disease co-existing functional dyspepsia on patients' daily lives: A prospective, observational study.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis.Journal of neurogastroenterology and motility · 2022Review
- Finding commonalities in rare diseases through the undiagnosed diseases network.Journal of the American Medical Informatics Association : JAMIA · 2021Observational
- Double Tract Reconstruction Reduces Reflux Esophagitis and Improves Quality of Life after Radical Proximal Gastrectomy for Patients with Upper Gastric or Esophagogastric Adenocarcinoma.Cancer research and treatment · 2021Article
- Profile of the Change in Depression during Proton-Pump Inhibitor Therapy in Patients with Gastroesophageal Reflux Disease: Influence of the Mucosal Break.International journal of environmental research and public health · 2021Article
- Are Anxious and Depressive Symptoms Associated with Gastrointestinal Symptoms in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)?Journal of racial and ethnic health disparities · 2021Article
- Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis.BMC gastroenterology · 2021Article
- The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Analysis of Psychological and Gut Microbiome Characteristics in Patients With Non-erosive Reflux Disease.Frontiers in psychiatry · 2021Article
- Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders.Journal of neurogastroenterology and motility · 2020Article
- Minor psychiatric disorders and objective diagnosis of gastroesophageal reflux disease.Surgical endoscopy · 2019Article
- Gastro Oesophageal Reflux Disease Shadowing Anxiety Disorder Causing Prolonged Exposure to Proton Pump Inhibitor.Korean journal of family medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence shows an influence relationship between described symptoms of gastroesophageal reflux disorder (GERD) and emotional state.
objectiveTo determine the relationship between anxiety and depression with GERD in patients referred to the endoscopy unit of Bouali-Sina Hospital in Qazvin.
methodsThis case-control study was conducted in the endoscopy unit of Bouali-Sina Hospital in Qazvin, Iran, from April 2014 through May 2015. Two hundred individuals (100 patients with GERD and 100 healthy individuals as a control group) were enrolled into the current study. All subjects completed the hospital anxiety and depression questionnaire. GERD was diagnosed based on the Los Angeles classification system. Demographic and socioeconomic characteristics in addition to clinical history of subjects were collected and analyzed using proper statistical methods (independent-samples t-test and AVOVA) and using SPSS version 22.
resultsAmong the recruited patients, 50 subjects had erosive esophagitis (ERD) and 50 had non-erosive esophagitis (NERD). The anxiety score was significantly higher in the NERD group than the ERD and control groups (p=0.017; p<0.001). In addition, the anxiety score was significantly higher in the ERD group than the control group (p=0.014). The score of depression was higher in the NERD group than the ERD and the control groups. However, this difference was not statistically significant for the ERD group (p=0.63), but the difference was significant in comparison to the control group (p<0.001). There was no significant difference among the groups regarding age, gender or body mass index (BMI). The number of smokers was significantly higher in the ERD group than the NERD and control groups (p<0.001).
conclusionThe current study showed that mental factors (anxiety and depression) play important roles in the development of GERD, especially NERD; therefore, it is recommended to consider these factors to select a suitable treatment plan.
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