ReviewJournal of the Intensive Care Society2017
The significance of circadian rhythms and dysrhythmias in critical illness.
Review in Journal of the Intensive Care Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The effect of sleep-wake behaviors on the onset of mania in youth: A computational model.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- AI-based prediction of VONPJ microgravity · 2025Article
- Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence.Aging and disease · 2025Review
- Postoperative circadian patterns in wearable sensor measured heart rate: a prospective observational study.Journal of clinical monitoring and computing · 2024Observational
- Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?Bipolar disorders · 2023Review
- Are We Ready for Video Recognition and Computer Vision in the Intensive Care Unit? A Survey.Applied clinical informatics · 2021Article
- Circadian Hygiene in the ICU Environment (CHIE) study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Article
- Analysis of changes in cardiac circadian rhythms of RR and QT induced by a 60-day head-down bed rest with and without nutritional countermeasure.European journal of applied physiology · 2020Article
- Dynamic Pituitary-Adrenal Interactions in the Critically Ill after Cardiac Surgery.The Journal of clinical endocrinology and metabolism · 2020Article
- Metabolomics Pilot Study Identifies Desynchronization of 24-H Rhythms and Distinct Intra-patient Variability Patterns in Critical Illness: A Preliminary Report.Frontiers in neurology · 2020Article
- Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study.Journal of intensive care · 2020Article
- Sleep and Circadian Rhythms in Survivors of Acute Respiratory Failure.Frontiers in neurology · 2020Article
- Evaluation of Cardiac Circadian Rhythm Deconditioning Induced by 5-to-60 Days of Head-Down Bed Rest.Frontiers in physiology · 2020Article
- Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study.Intensive care medicine experimental · 2019Article
- Time of Day and its Association with Risk of Death and Chance of Discharge in Critically Ill Patients: A Retrospective Study.Scientific reports · 2019Article
- Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning.Scientific reports · 2019Observational
- Article
- Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study.Annals of intensive care · 2018Article
- Development of ultra-low volume, multi-bio fluid, cortisol sensing platform.Scientific reports · 2018Article
- Clinical chronobiology: a timely consideration in critical care medicine.Critical care (London, England) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many physiological and cellular processes cycle with time, with the period between one peak and the next being roughly equal to 24 h. These circadian rhythms underlie 'permissive homeostasis', whereby anticipation of periods of increased energy demand or stress may enhance the function of individual cells, organ systems or whole organisms. Many physiological variables related to survival during critical illness have a circadian rhythm, including the sleep/wake cycle, haemodynamic and respiratory indices, immunity and coagulation, but their clinical significance remains underappreciated. Critically ill patients suffer from circadian dysrhythmia, manifesting overtly as sleep disturbance and delirium, but with widespread covert effects on cellular and organ function. Environmental and pharmacological strategies that ameliorate or prevent circadian dysrhythmia have demonstrated clinical benefit. Harnessing these important biological phenomena to match metabolic supply to demand and bolster cell defenses at the apposite time may be a future therapeutic strategy in the intensive care unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.