Evidence map›Paper›PMID 28979294›Full record

ArticleFrontiers in genetics2017

Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from

Omolara-Chinue Glenn, Lidia Tagliafierro, Thomas G Beach, Randy L Woltjer, Ornit Chiba-Falek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Intronic enhancers of the humanScience advances · 2022
    Article
  4. Genetic Elements at the Alpha-Synuclein Locus.Frontiers in neuroscience · 2022
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Omolara-Chinue GlennDepartment of Neurology, Duke University Medical Center, DurhamNC, United States.
Lidia TagliafierroDepartment of Neurology, Duke University Medical Center, DurhamNC, United States.
Thomas G BeachBanner Sun Health Research Institute, Sun CityAZ, United States.
Randy L WoltjerLayton Aging and Alzheimer's Disease Center, Department of Pathology, Oregon Health and Science University, PortlandOR, United States.
Ornit Chiba-FalekDepartment of Neurology, Duke University Medical Center, DurhamNC, United States.
Duke Medical Center · USBanner Sun Health Research Institute · USOregon Health & Science University · US

Funding

Lewy body neuropathologies and SNCA gene: variants expression and splicingR01NS085011 · NINDS · DUKE UNIVERSITY · PI CHIBA-FALEK, ORNIT · 2013 to 2017
$1.8M
NINDS NIH HHS R01 NS085011
6 · The paper itself

Abstract

The

Indexed as

gene expressionParkinson’s diseaseSNCA genetranslation of GWAS findings

Identifiers

PMID28979294
PMCPMC5611418
OpenAlexW2756026656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.