ArticleFrontiers in aging neuroscience2017
Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 130 citations in OpenAlex.
- Effect of orofacial physiotherapeutic and hygiene interventions on oral health-related quality of life in patients with Parkinson's disease: A randomised controlled trial.Journal of oral rehabilitation · 2021Trial
- Utility of Baseline Pathological, Neuroimaging and Clinical Markers for Prognosis in Early Parkinson's Disease.Journal of geriatric psychiatry and neurology · 2026Article
- Denoised MDS-UPDRS part-III scores yield new patterns of progression heterogeneity in early stage Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Denoised MDS-UPDRS Part-III Scores Yield New Patterns of Progression Heterogeneity in Early Stage Parkinson's Disease.bioRxiv : the preprint server for biology · 2026Article
- Many Moving Parts: A Motor-Based Perspective on Developmental Speech and Language Research in Neurodevelopmental Disorders.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Retinal electrophysiological responses to dopaminergic therapy in treatment naïve Parkinson's disease.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- A transdiagnostic approach to non-motor symptoms in Parkinson's disease: exploring internalizing, bipolar spectrum, and impulsive compulsive behavior profiles via cluster analysis.Frontiers in aging neuroscience · 2026Article
- Parkinson's disease beyond motor symptoms: a review of the validity and limitations of current classification of non-motor symptoms.Frontiers in psychiatry · 2026Review
- Disease activity classification based on routinely collected blood tests in a prospective paediatric inflammatory bowel disease inception cohort.Journal of pediatric gastroenterology and nutrition · 2026Article
- Identification of a Novel Subtype of Ocular Hypertensive Eyes with the Lowest Risk of Progression Under Treatment.Ophthalmology and therapy · 2025Article
- Exploring Motor-Cognitive Interference Effects and the Influence of Self-Reported Physical Activity on Dual-Task Walking in Parkinson's Disease and Healthy Older Adults.Brain sciences · 2025Article
- Behavior classification: Introducing machine learning approaches for classification of sign-tracking, goal-tracking and beyond.PloS one · 2025Article
- Medication recommendation for Parkinson's disease based on dynamics of symptom progression.Scientific reports · 2024Article
- Identifying and verifying Huntington's disease subtypes: Clinical features, neuroimaging, and cytokine changes.Brain and behavior · 2024Article
- Differences in brain aging between sexes in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Future Directions for Developing Non-dopaminergic Strategies for the Treatment of Parkinson's Disease.Current neuropharmacology · 2024Review
- Article
- Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.Frontiers in neuroscience · 2024Article
- Temporal patterns of sleep latency in central hypersomnia and attention deficit hyperactivity disorder: a cluster analysis exploration using Multiple Sleep Latency Test.Frontiers in psychiatry · 2024Article
- Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment.Brain and behavior · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor to end stages. To understand the clinical heterogeneity of Parkinson's disease, this study used cluster analysis to search for subtypes from a large, multi-center, international, and well-characterized cohort of Parkinson's disease patients across all motor stages, using a combination of cardinal motor features (bradykinesia, rigidity, tremor, axial signs) and, for the first time, specific validated rater-based non-motor symptom scales. Two independent international cohort studies were used: (a) the validation study of the Non-Motor Symptoms Scale (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.