Evidence map›Paper›PMID 28979176›Full record

ArticleClinical medicine insights. Case reports2017

Noncanonical Adult Human Neurogenesis and Axonal Growth as Possible Structural Basis of Recovery From Traumatic Vegetative State.

Yulia Vainshenker, Vsevolod Zinserling, Alexander Korotkov, Svyatoslav Medvedev

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine insights. Case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yulia VainshenkerN.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (IHB RAS), Saint Petersburg, Russia.
Vsevolod ZinserlingDepartment of Pathology, Saint Petersburg State University, Saint Petersburg, Russia.
Alexander KorotkovN.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (IHB RAS), Saint Petersburg, Russia.
Svyatoslav MedvedevN.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (IHB RAS), Saint Petersburg, Russia.
Institute of the Human Brain · RUClinical Infectious Disease Hospital named after S.P. Botkin · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient recovering from traumatic vegetative state has suddenly died from cardiac arrest. In-life improvement of consciousness appeared after reduction of generalized spasticity due to botulinum toxin administration. Neuropathologic examination revealed Musashi1+, Nestin+, PCNA+, and Ki67+ cells in the hippocampus, frontal, parietal and occipital cortex, caudate, thalamus, mammillary bodies, brainstem, cerebellum, and near the posterior horn of the lateral ventricle. New neurons with neurite growth (TUC4+) appeared in corpus callosum. At the same time, axonal growth was detected in all areas of interest. New cells whose functional state was continuously improving, as revealed by in-life neurologic and positron emission tomography monitoring, have mainly been found in brain areas without neuropathologic signs of damage. We suggest that the possible role of neurogenesis consists in improvement of the microenvironment and interneuron interactions, whereas the activation of neurogenesis and the induction of neurite growth may be associated with reduction of spasticity.

Indexed as

adult human neurogenesisaxonal growthbotulinum toxin therapy of spasticityfunctional state of the brainimprovement of consciousnessvegetative state

Identifiers

PMID28979176
PMCPMC5617086
OpenAlexW2760721941

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.