ArticleScientific reports2017
The innate immune cell response to bacterial infection in larval zebrafish is light-regulated.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Temperature and photoperiod stress in zebrafish larvae: impacts on development, gene regulation and PGC migration.Fish physiology and biochemistry · 2025Article
- Heat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells.Scientific reports · 2024Article
- Article
- Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users.F1000Research · 2023Review
- Immunity, Infection, and the Zebrafish Clock.Infection and immunity · 2022Review
- Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.Journal of neuroinflammation · 2022Review
- Endocrine, immune and renal toxicity in male largemouth bass after chronic exposure to glyphosate and Rodeo®.Aquatic toxicology (Amsterdam, Netherlands) · 2022Article
- The circadian clock modulates Anopheles gambiae infection with Plasmodium falciparum.PloS one · 2022Article
- Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae.Current research in immunology · 2021Article
- Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish.Frontiers in psychiatry · 2021Article
- The evolutionary ecology of circadian rhythms in infection.Nature ecology & evolution · 2019Article
- Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.Disease models & mechanisms · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock, which evolved to help organisms harmonize physiological responses to external conditions (such as the light/dark cycle, LD), is emerging as an important regulator of the immune response to infection. Gaining a complete understanding of how the circadian clock influences the immune cell response requires animal models that permit direct observation of these processes within an intact host. Here, we investigated the use of larval zebrafish, a powerful live imaging system, as a new model to study the impact of a fundamental zeitgeber, light, on the innate immune cell response to infection. Larvae infected during the light phase of the LD cycle and in constant light condition (LL) demonstrated enhanced survival and bacterial clearance when compared with larvae infected during the dark phase of the LD cycle and in constant dark condition (DD). This increased survival was associated with elevated expression of the zebrafish orthologues of the mammalian pro-inflammatory cytokine genes, Tumour necrosis factor-α, Interleukin-8 and Interferon-γ, and increased neutrophil and macrophage recruitment. This study demonstrates for the first time that the larval zebrafish innate immune response to infection is enhanced during light exposure, suggesting that, similar to mammalian systems, the larval zebrafish response to infection is light-regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.