ArticleJCI insight2017
New insights on glomerular hyperfiltration: a Japanese autopsy study.
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
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- Nephron number variability in Japanese subjects: an autopsy-based study and its implications for chronic kidney disease: clinical scientist award address 2024.Clinical and experimental nephrology · 2025Review
- Relationship among nephron number, cortical volume, and glomerular pressure in healthy kidney donors.Physiological reports · 2025Article
- Estimating Number of Nephrons in Living Pediatric Patients Using Nephrectomy Specimens.Kidney international reports · 2025Article
- Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.Journal of nephrology · 2023Article
- Nephrons, podocytes and chronic kidney disease: Strategic antihypertensive therapy for renoprotection.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- No NLRP3 inflammasome activity in kidney epithelial cells, not even when the NLRP3-A350V Muckle-Wells variant is expressed in podocytes of diabetic mice.Frontiers in immunology · 2023Article
- Low glomerular number at birth can lead to the development of chronic kidney disease.Frontiers in endocrinology · 2023Review
- Impact of Cabozantinib Exposure on Proteinuria and Muscle Toxicity in Patients with Unresectable Hepatocellular Carcinoma.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Kidney glomerular filtration rate plasticity after transplantation.Clinical kidney journal · 2022Article
- The distribution of eGFR by age in a community-based healthy population: the Japan specific health checkups study (J-SHC study).Clinical and experimental nephrology · 2021Article
- Impact of lenvatinib on renal function: long-term analysis of differentiated thyroid cancer patients.BMC cancer · 2021Article
- Renal function outcomes and kidney biopsy features of living kidney donors with hypertension.Clinical transplantation · 2021Article
- Assessment of nephron number and single-nephron glomerular filtration rate in a clinical setting.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- Nephron number and its determinants: a 2020 update.Pediatric nephrology (Berlin, Germany) · 2021Article
- New imaging tools to measure nephron numberJournal of developmental origins of health and disease · 2021Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease (CKD). The incidence of CKD in Japan is among the highest in the world, but the reasons remain unclear. We estimated total nephron (glomerular) number (NglomTOTAL) as well as numbers of nonsclerosed (NglomNSG) and globally sclerosed glomeruli (NglomGSG), and the mean volume of nonsclerosed glomeruli (VglomNSG) in Japanese normotensive, hypertensive, and CKD subjects and investigated associations between these parameters and estimated glomerular filtration rate (eGFR). Autopsy kidneys from age-matched Japanese men (9 normotensives, 9 hypertensives, 9 CKD) had nephron number and VglomNSG estimated using disector/fractionator stereology. Subject eGFR, single-nephron eGFR (SNeGFR), and the ratio SNeGFR/VglomNSG were calculated. NglomNSG in Japanese with hypertension (392,108 ± 87,605; P < 0.001) and CKD (268,043 ± 106,968; P < 0.001) was less than in normotensives (640,399 ± 160,016). eGFR was directly correlated with NglomNSG (r = 0.70, P < 0.001) and inversely correlated with VglomNSG (r = -0.53, P < 0.01). SNeGFR was higher in hypertensives than normotensives (P = 0.03), but was similar in normotensives and CKD, while the ratio SNeGFR/VglomNSG was similar in normotensives and hypertensives but markedly reduced in CKD. Nephron number in Japanese with hypertension or CKD was low. This results in a higher SNeGFR in hypertensives compared with normotensive and CKD subjects, but lowered SNeGFR/VglomNSG in CKD subjects, suggesting that changes in GFR are accommodated by glomerular hypertrophy rather than glomerular hypertension. These findings suggest glomerular hypertrophy is a dominant factor in maintenance of GFR under conditions of low nephron number.
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