Evidence map›Paper›PMID 28978770›Full record

ReviewGenetics2017

Emerging Properties and Functional Consequences of Noncoding Transcription.

Ryan Ard, Robin C Allshire, Sebastian Marquardt

Abstract readReview
In one paragraph

Review in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. A long noncoding RNA at theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Emerging Functions of lncRNA Loci beyond the Transcript Itself.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Microarray Analysis of Whole-Transcriptome RNAs Including Non-Coding RNAs.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryan ArdCopenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark.ORCID 0000-0002-9070-9747
Robin C AllshireWellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, EH9 3BF, Scotland, UK.
Sebastian MarquardtCopenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark sebastian.marquardt@plen.ku.dk.ORCID 0000-0003-1709-2717

Funding

Wellcome Trust 200885/Z/16/Z
6 · The paper itself

Abstract

Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

Indexed as

AnimalsChromatinHumansRNA, Long NoncodingRNA Polymerase IIRNA StabilityTranscription, GeneticChromatinRNA, Long NoncodingRNA Polymerase IIchromatingene regulationlong noncoding RNA (lncRNA)nascent transcriptionnoncoding transcriptionRNA Polymerase II transcriptiontranscriptional interferencetranscription cycle

Identifiers

PMID28978770
PMCPMC5629311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.