ArticleJournal of neurophysiology2018
Layer- and subregion-specific differences in the neurophysiological properties of rat medial prefrontal cortex pyramidal neurons.
Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Acute Stress Drives Adaptive Anxiety via Excitatory-Inhibitory Imbalance in the Prefrontal-Amygdala Circuit in Male Mice.Neuroscience bulletin · 2026Article
- Brief high-fat diet exposure temporally reshapes affective behavior and prefrontal cortex function.bioRxiv : the preprint server for biology · 2026Article
- A prefrontal cortex-nucleus accumbens circuit attenuates cocaine-conditioned place preference memories.Molecular psychiatry · 2026Article
- Oxytocin agonist TGOT differentially modulates synaptic plasticity and intrinsic excitability in a sex-specific manner in the juvenile rat hippocampus.Communications biology · 2026Article
- Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers.bioRxiv : the preprint server for biology · 2026Article
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
- Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture.Biological psychiatry global open science · 2026Article
- Article
- Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Retrieval of conditioned immune response in male mice is mediated by an anterior-posterior insula circuit.Nature neuroscience · 2025Article
- An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.bioRxiv : the preprint server for biology · 2024Article
- Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain.Nature neuroscience · 2023Article
- Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress.Cell & bioscience · 2023Article
- Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages.Experimental neurobiology · 2022Review
- Spontaneous synchronous network activity in the neonatal development of mPFC in mice.Developmental neurobiology · 2021Article
- General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism.Frontiers in cellular neuroscience · 2021Article
- Systematic modelling of the development of laminar projection origins in the cerebral cortex: Interactions of spatio-temporal patterns of neurogenesis and cellular heterogeneity.PLoS computational biology · 2020Article
- Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit.Neurobiology of learning and memory · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Medial prefrontal cortex (mPFC) is critical for the expression of long-term conditioned fear. However, the neural circuits involving fear memory acquisition and retrieval are still unclear. Two subregions within mPFC that have received a lot of attention are the prelimbic (PL) and infralimbic (IL) cortices (e.g., Santini E, Quirk GJ, Porter JT. J Neurosci 28: 4028-4036, 2008; Song C, Ehlers VL, Moyer JR Jr J Neurosci 35: 13511-13524, 2015). Interestingly, PL and IL may play distinct roles during fear memory acquisition and retrieval but the underlying mechanism is poorly understood. One possibility is that the intrinsic membrane properties differ between these subregions. Thus, the current study was carried out to characterize the basic membrane properties of mPFC neurons in different layers and subregions. We found that pyramidal neurons in L2/3 were more hyperpolarized and less excitable than in L5. This was observed in both IL and PL and was associated with an enhanced h-current in L5 neurons. Within L2/3, IL neurons were more excitable than those in PL, which may be due to a lower spike threshold and higher input resistance in IL neurons. Within L5, the intrinsic excitability was comparable between neurons obtained in IL and PL. Thus, the heterogeneity in physiological properties of mPFC neurons may underlie the observed subregion-specific contribution of mPFC in cognitive function and emotional control, such as fear memory expression. NEW & NOTEWORTHY This is the first study to demonstrate that medial prefrontal cortical (mPFC) neurons are heterogeneous in both a layer- and a subregion-specific manner. Specifically, L5 neurons are more depolarized and more excitable than those neurons in L2/3, which is likely due to variations in h-current. Also, infralimbic neurons are more excitable than those of prelimbic neurons in layer 2/3, which may be due to differences in certain intrinsic properties, including input resistance and spike threshold.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.