ArticleJournal of the Royal Society, Interface2017
Tissue loading and microstructure regulate the deformation of embedded nerve fibres: predictions from single-scale and multiscale simulations.
Article in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Bridging Temporomandibular Joint Structure, Function, and Pain: An Integrated Multiscale Perspective.Journal of dental research · 2026Review
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Histology-informed multiscale modeling of human brain white matter.Scientific reports · 2023Article
- Cervical facet capsular ligament mechanics: Estimations based on subject-specific anatomy and kinematics.JOR spine · 2023Article
- Characterization of the L4/L5 rat facet capsular ligament macromechanical and microstructural responses to tensile failure loading.Journal of biomechanics · 2023Article
- The Lumbar Facet Capsular Ligament Becomes More Anisotropic and the Fibers Become Stiffer With Intervertebral Disc and Facet Joint Degeneration.Journal of biomechanical engineering · 2023Article
- 3D-printed auxetic-structured intervertebral disc implant for potential treatment of lumbar herniated disc.Bioactive materials · 2023Article
- In Situ Lumbar Facet Capsular Ligament Strains Due to Joint Pressure and Residual Strain.Journal of biomechanical engineering · 2022Article
- Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model.Biomechanics and modeling in mechanobiology · 2021Article
- Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction.Scientific reports · 2020Article
- Multiscale modelling of the human lumbar facet capsular ligament: analysing spinal motion from the joint to the neurons.Journal of the Royal Society, Interface · 2018Article
- The role of the facet capsular ligament in providing spinal stability.Computer methods in biomechanics and biomedical engineering · 2018Article
- Repeated High Rate Facet Capsular Stretch at Strains That are Below the Pain Threshold Induces Pain and Spinal Inflammation With Decreased Ligament Strength in the Rat.Journal of biomechanical engineering · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Excessive deformation of nerve fibres (axons) in the spinal facet capsular ligaments (FCLs) can be a cause of pain. The axons are embedded in the fibrous extracellular matrix (ECM) of FCLs, so understanding how local fibre organization and micromechanics modulate their mechanical behaviour is essential. We constructed a computational discrete-fibre model of an axon embedded in a collagen fibre network attached to the axon by distinct fibre-axon connections. This model was used to relate the axonal deformation to the fibre alignment and collagen volume concentration of the surrounding network during transverse, axial and shear deformations. Our results showed that fibre alignment affects axonal deformation only during transverse and axial loading, but higher collagen volume concentration results in larger overall axonal strains for all loading cases. Furthermore, axial loading leads to the largest stretch of axonal microtubules and induces the largest forces on axon's surface in most cases. Comparison between this model and a multiscale continuum model for a representative case showed that although both models predicted similar averaged axonal strains, strain was more heterogeneous in the discrete-fibre model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.