ArticleProceedings. Biological sciences2017
Novel and divergent genes in the evolution of placental mammals.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative Phylogenetics Reveal Clade-specific Drivers of Recombination Rate Evolution Across Vertebrates.Molecular biology and evolution · 2025Article
- A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.Communications biology · 2023Article
- The draft genome of the microscopicFrontiers in genetics · 2023Article
- Large-scale placenta DNA methylation integrated analysis reveals fetal sex-specific differentially methylated CpG sites and regions.Scientific reports · 2022Article
- Mammalian tumor-like organs. 1. The role of tumor-like normal organs and atypical tumor organs in the evolution of development (carcino-evo-devo).Infectious agents and cancer · 2022Review
- Genetic Mechanisms Underlying Cortical Evolution in Mammals.Frontiers in cell and developmental biology · 2021Review
- Emerging roles of the MAGE protein family in stress response pathways.The Journal of biological chemistry · 2020Review
- The genetic factors of bilaterian evolution.eLife · 2020Article
- Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation.Genome biology and evolution · 2020Article
- Gene Fusions Derived by Transcriptional Readthrough are Driven by Segmental Duplication in Human.Genome biology and evolution · 2019Article
- MAGE cancer-testis antigens protect the mammalian germline under environmental stress.Science advances · 2019Article
- Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty.Nature communications · 2018Article
- The Role of Heritable Tumors in Evolution of Development: a New Theory of Carcino-evo-devo.Acta naturaeArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-versus-all reciprocal BLASTP to identify and phylogenetically date 'Homology Groups' among vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focusing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.
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