ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Identification of IL-40, a Novel B Cell-Associated Cytokine.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Updating the symbols of ten cytokines and their receptors: report of the IUIS Cytokine Nomenclature Sub-Committee.Nature immunology · 2026Article
- "IL-40: A novel immunoregulatory axis at the crossroads of inflammation, tissue remodeling, and cancer immunity".Immunologic research · 2026Review
- Interleukin-40 in Systemic Sclerosis: A Treatment-Sensitive Marker of Immune Modulation Rather Than Disease Activity.Clinical and translational science · 2026Article
- The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm.Biomarker research · 2026Review
- Peripheral blood mRNA expression of IL37, IL1F10, and C17orf99 genes is altered in patients with B-acute lymphoblastic leukemia: a case-control study.Molecular biology reports · 2026Article
- Deficiency of interleukin-40 prevents intestinal damage in experimental necrotizing enterocolitis by inhibiting NETosis.Cell communication and signaling : CCS · 2026Article
- IL40: A Newly Described Cytokine With Conflicting Measurements and Detection Variability-Are There Different Forms?Scandinavian journal of immunology · 2026Article
- Interleukin-40 as a biomarker of mortality risk in patients with severe pneumonia.Frontiers in immunology · 2026Article
- Unveiling Interleukin-40: A Novel Regulator of Macrophage and B Cell Function in Allergic Asthma.International journal of biological sciences · 2026Article
- Nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin levels in patients undergoing coronary artery bypass grafting.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Serum Interleukin-40 and Soluble CD40 Ligand as Complementary Biomarkers for Disease Activity in Multiple Sclerosis Patients.Medeniyet medical journal · 2025Article
- Interleukin-40 and Oxidative Stress in Patients With Generalized Anxiety Disorder.Psychiatry investigation · 2025Article
- Serum IL-40 is elevated in systemic sclerosis and is linked to disease activity, gastrointestinal involvement, immune regulation and fibrotic processes.Arthritis research & therapy · 2025Article
- Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis.Critical care (London, England) · 2025Article
- Serum interleukin-40 increases in anti-AchR antibody-positive myasthenia gravis and correlates with disease activity.Frontiers in neurology · 2025Article
- Increased serum levels of IL-40 are associated with IgA and NETosis biomarkers in Covid-19 patients: IL-40 and infectious diseases.PloS one · 2025Article
- IL-40 levels in treatment-naive and methotrexate-treated rheumatoid arthritis patients.Turkish journal of medical sciences · 2025Article
- Serum IL-40 increases in patients with rheumatoid arthritis and correlates with some clinical characteristics and comorbidities.Scientific reports · 2024Article
- Investigating the role of salivary Interleukin-40 levels in diagnosing periodontal diseases.Oral diseases · 2024Article
- Investigation of pre and postoperative Th1/Th2 cytokine balance and novel cytokines in colorectal cancer patients.Clinical and experimental medicine · 2024Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Jovani Catalan-DibeneDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Monica I VazquezDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Van Phi LuuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Sean-Paul NuccioDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697; and.ORCID 0000-0002-9683-9278
Alborz KarimzadehDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697.
Jenna M KastenschmidtDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
S Armando VillaltaDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Irina UshachDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Egest J PoneInstitute for Immunology, University of California, Irvine, Irvine, CA 92697.
Paolo CasaliInstitute for Immunology, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-8982-5177
Manuela RaffatelluDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697; and.ORCID 0000-0001-6487-4215
Amanda M BurkhardtDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Marcela Hernandez-RuizDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Gina HellerDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
Peter A HeveziDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-1906-5846
Albert ZlotnikDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; azlotnik@uci.edu.
University of California, Irvine · US
Funding
MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3MIntrinsic B cell epigenetic regulation of antibody and autoantibody responses by Sirt1R01AI105813 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2014 to 2023
$4.5MSomatic hypermutation and class switching in autoimmunityR01AI079705 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2010 to 2019
$4.1MImmunology Research Training ProgramT32AI060573 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2005 to 2020
$1.9MFunctional characterization of IL-40, a novel cytokineR21AI117556 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZLOTNIK, ALBERT · 2015 to 2016
$425kCharacterization of IL36, a novel cytokineR21AI096278 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZLOTNIK, ALBERT · 2011 to 2012
$406kMolecular mechanisms in the generation of autoantibodies and lupusR56AI079705 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2008 to 2008
$381kEpigenetic downregulation of the antibody response and inhibition of autoimmunityR56AI105813 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2013 to 2013
$286kNIAID NIH HHS R01 AI079705NIAID NIH HHS R01 AI105813NIAID NIH HHS R21 AI096278NIAID NIH HHS R21 AI117556NIAID NIH HHS R56 AI079705NIAID NIH HHS R56 AI105813NIAID NIH HHS T32 AI060573NIGMS NIH HHS R25 GM055246
Abstract
We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (
Indexed as
AnimalsB-LymphocytesGene Expression RegulationHumansImmunoglobulin AInterleukinsJurkat CellsLymphoma, B-CellMiceMice, KnockoutPeyer's PatchesImmunoglobulin AInterleukins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.