ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Medial Frontal Theta Is Entrained to Rewarded Actions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Sensorimotor Theta Oscillations Coordinate Speech Movements.bioRxiv : the preprint server for biology · 2025Article
- Repeated alcohol drinking in mice is associated with bidirectional alterations in corticostriatal coherence.Neuropharmacology · 2025Article
- Article
- Theta oscillation synchronize VTA and mPFC during ethanol-induced conditioned place preference and stress-evoked anxiety.Translational psychiatry · 2025Article
- Article
- Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.International journal of bipolar disorders · 2023Article
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
- Behavioral State-Dependent Modulation of Prefrontal Cortex Activity by Respiration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The rostral medial frontal cortex is crucial for engagement in consummatory behavior.Behavioral neuroscience · 2022Article
- Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatum.Current biology : CB · 2022Article
- Eating driven by the gustatory insula: contrasting regulation by infralimbic vs. prelimbic cortices.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction.Addiction biology · 2022Article
- Coherent theta activity in the medial and orbital frontal cortices encodes reward value.eLife · 2021Article
- Integration of value and action in medial prefrontal neural systems.International review of neurobiology · 2021Review
- Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.International review of neurobiology · 2021Review
- Dissociation of Medial Frontal β-Bursts and Executive Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence.Scientific reports · 2020Article
- A New Unifying Account of the Roles of Neuronal Entrainment.Current biology : CB · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Rodents lick to consume fluids. The reward value of ingested fluids is likely to be encoded by neuronal activity entrained to the lick cycle. Here, we investigated relationships between licking and reward signaling by the medial frontal cortex (MFC), a key cortical region for reward-guided learning and decision-making. Multielectrode recordings of spike activity and field potentials were made in male rats as they performed an incentive contrast licking task. Rats received access to higher- and lower-value sucrose rewards over alternating 30 s periods. They learned to lick persistently when higher-value rewards were available and to suppress licking when lower-value rewards were available. Spectral analysis of spikes and fields revealed evidence for reward value being encoded by the strength of phase-locking of a 6-12 Hz theta rhythm to the rats' lick cycle. Recordings during the initial acquisition of the task found that the strength of phase-locking to the lick cycle was strengthened with experience. A modification of the task, with a temporal gap of 2 s added between reward deliveries, found that the rhythmic signals persisted during periods of dry licking, a finding that suggests the MFC encodes either the value of the currently available reward or the vigor with which rats act to consume it. Finally, we found that reversible inactivations of the MFC in the opposite hemisphere eliminated the encoding of reward information. Together, our findings establish that a 6-12 Hz theta rhythm, generated by the rodent MFC, is synchronized to rewarded actions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.