ArticleAmerican journal of physiology. Endocrinology and metabolism2018
Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise.
Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density.International journal of environmental research and public health · 2022Trial
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
- Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.Experimental physiology · 2025Article
- Article
- Daily GDF15 treatment has sex-specific effects on body weight and food intake and does not enhance the effects of voluntary physical activity in mice.The Journal of physiology · 2024Article
- Exercise-induced regulation of adipose tissue.Current opinion in genetics & development · 2023Review
- The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued bycilostamide.Physiological reports · 2022Article
- Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity.Metabolites · 2021Article
- Sexual Dimorphic Effects of Exercise Training on Subcutaneous White Adipose Tissue of Mice.Diabetes · 2021Article
- The confounding effects of sub-thermoneutral housing temperatures on aerobic exercise-induced adaptations in mouse subcutaneous white adipose tissue.Biology letters · 2021Article
- Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats.Physiological reports · 2020Article
- Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans.International journal of environmental research and public health · 2020Article
- Epinephrine responsiveness is reduced in livers from trained mice.Physiological reports · 2020Article
- Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue.American journal of physiology. Cell physiology · 2020Article
- [Time-sequential expression of lnc AK079912 during adipose tissue development and browning in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.Journal of lipid research · 2019Article
- Looking on the "brite" side exercise-induced browning of white adipose tissue.Pflugers Archiv : European journal of physiology · 2019Review
- Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue.iScience · 2019Article
- Effects of exercise on brown and beige adipocytes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Exercise training has robust effects on subcutaneous inguinal white adipose tissue (iWAT), characterized by a shift to a brown adipose tissue (BAT)-like phenotype. Consistent with this, transplantation of exercise-trained iWAT into sedentary rodents activates thermogenesis and improves glucose homeostasis, suggesting that iWAT metabolism may contribute to the beneficial effects of exercise. However, it is yet to be determined if adaptations in iWAT are necessary for the beneficial systemic effects of exercise. To test this, male C57BL/6 mice were provided access to voluntary wheel running (VWR) or remained as a cage control (SED) for 11 nights after iWAT removal via lipectomy (LIPX) or SHAM surgery. We found that SHAM and LIPX mice with access to VWR ran similar distances and had comparable reductions in body mass, increased food intake, and increased respiratory exchange ratio (RER). Further, VWR improved indexes of glucose homeostasis and insulin tolerance in both SHAM and LIPX mice. The lack of effect of LIPX in the response to VWR was not explained by compensatory increases in markers of mitochondrial biogenesis and thermogenesis in skeletal muscle, epididymal white adipose tissue, or interscapular brown adipose tissue. Together, these data demonstrate that mice with and without iWAT have comparable adaptations to VWR, suggesting that iWAT may be dispensable for the metabolic health benefits of exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.