Evidence map›Paper›PMID 28978524›Full record

ArticleAmerican journal of physiology. Cell physiology2017

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.

Travis Lear, Sarah R Dunn, Alison C McKelvey, Aazrin Mir, John Evankovich, Bill B Chen, Yuan Liu

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Travis LearDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID http://orcid.org/0000-0001-9156-0844
Sarah R DunnDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.
Alison C McKelveyDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.
Aazrin MirDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.
John EvankovichDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.
Bill B ChenDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania.
Yuan LiuDepartment of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania; liuy13@upmc.edu.
University of Pittsburgh · US

Funding

Translational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3M
Role of F-Box Proteins in Lung TransplantationR01HL133184 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI, MCDYER, JOHN F · 2017 to 2020
$2.1M
Regulation of Innate Immunity by F-Box ProteinsR01HL116472 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2013 to 2017
$1.9M
HECT-domain E3 Ligase and Acute Lung InjuryR01HL132862 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2016 to 2017
$976k
NHLBI NIH HHS R01 HL116472NHLBI NIH HHS R01 HL132862NHLBI NIH HHS T32 HL007563
6 · The paper itself

Abstract

As an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also called CXCL12), C-X-C chemokine receptor type 4 (CXCR4) plays a vital role in chemotactically attracting lymphocytes during inflammation. CXCR4 also regulates HIV infection due to its role as one of the chemokine coreceptors for HIV entry into CD4

Indexed as

DNA-Binding ProteinsHeLa CellsHIV InfectionsHumansProtein StabilityReceptors, CXCR4Signal TransductionUbiquitinationUbiquitin-Protein LigasesCXCR4 protein, humanDNA-Binding ProteinsReceptors, CXCR4RNF113A protein, humanUbiquitin-Protein Ligasescell migrationCXCR4RING E3 ligaseubiquitination

Identifiers

PMID28978524
PMCPMC5792167
OpenAlexW2761229076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.