Evidence map›Paper›PMID 28978515›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR.

Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposure.American journal of physiology. Heart and circulatory physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Amy L WooldridgeRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Robert J BischofThe Ritchie Centre, Hudson Institute of Medical Research , Clayton, Victoria , Australia.
Hong LiuRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Gary K HeinemannRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Damien S HunterRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Lynne C GilesRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Rebecca A SimmonsPerelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
Yu-Chin LienPerelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
Wenyun LuLewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Princeton, New Jersey.
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Princeton, New Jersey.
Karen L KindRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Julie A OwensRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Vicki L CliftonRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.
Kathryn L GatfordRobinson Research Institute, University of Adelaide , Adelaide, South Australia , Australia.ORCID 0000-0002-2823-3004
The University of Adelaide · AUPrinceton University · USUniversity of Pennsylvania · USHudson Institute of Medical Research · AUTranslational Research Institute · AU

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest that restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined, but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. Therefore, we examined whether late-gestation maternal dietary methyl donor and cofactor supplementation of the placentally restricted (PR) sheep pregnancy would reverse allergic protection in progeny. Allergic outcomes were compared between progeny from control pregnancies (CON; n = 49), from PR pregnancies without intervention (PR; n = 28), and from PR pregnancies where the dam was fed a methyl donor plus cofactor supplement from day 120 of pregnancy until delivery (PR + Methyl; n = 25). Both PR and PR + Methyl progeny were smaller than CON; supplementation did not alter birth size. PR was protective against cutaneous hypersensitivity responses to ovalbumin (OVA; P < 0.01 in singletons). Cutaneous hypersensitivity responses to OVA in PR + Methyl progeny were intermediate to and not different from the responses of CON and PR sheep. Cutaneous hypersensitivity responses to house dust mites did not differ between treatments. In singleton progeny, upper dermal mast cell density was greater in PR + Methyl than in PR or CON (each P < 0.05). The differences in the cutaneous allergic response were not explained by treatment effects on circulating immune cells or antibodies. Our results suggest that mechanisms underlying in utero programming of allergic susceptibility by IUGR and methyl donor availability may differ and imply that late-gestation methyl donor supplementation may increase allergy risk.

Indexed as

Dietary SupplementsPrenatal Exposure Delayed EffectsAnimalsCobaltDermatitisDisease Models, AnimalDNA MethylationFemaleFetal Growth RetardationFolic AcidGestational AgeHypersensitivityImmunoglobulin EMast CellsMethionineOvalbuminCobaltFolic AcidImmunoglobulin EMethionineOvalbuminSulfuranimal modelsfetal growthfolic acidintrauterine growth restrictionmast cellsmethyl donors

Identifiers

PMID28978515
PMCPMC5866368
OpenAlexW2761887556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.