Evidence map›Paper›PMID 28978485›Full record

ArticleCell reports2017

An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABA

Elizabeth C Davenport, Valentina Pendolino, Georgina Kontou, Thomas P McGee, David F Sheehan, Guillermo López-Doménech, Mark Farrant, Josef T Kittler

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Direct modulation of human GABA-A αFrontiers in neuroscience · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Haploinsufficiency of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. GABAFrontiers in cellular neuroscience · 2024
    Article
  12. Established and emerging GABAFrontiers in pharmacology · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Impact of Developmental Changes of GABAInternational journal of molecular sciences · 2023
    Article
  17. Article
  18. Clptm1, a new target in suppressing epileptic seizure by regulating GABAThe Kaohsiung journal of medical sciences · 2023
    Article
  19. Shisa7-Dependent Regulation of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  20. Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elizabeth C DavenportDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Valentina PendolinoDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Georgina KontouDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Thomas P McGeeDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
David F SheehanDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Guillermo López-DoménechDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Mark FarrantDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: m.farrant@ucl.ac.uk.
Josef T KittlerDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: j.kittler@ucl.ac.uk.
University College London · GB

Funding

Medical Research Council G0802377Medical Research Council MR/J012998/1Medical Research Council MR/K015826/1
6 · The paper itself

Abstract

Inhibitory synaptic transmission requires the targeting and stabilization of GABA

Indexed as

AnimalsCA1 Region, HippocampalCarrier ProteinsChlorocebus aethiopsCOS CellsEmbryo, MammalianFemaleGene Expression RegulationInhibitory Postsynaptic PotentialsInterneuronsMaleMembrane ProteinsMicePatch-Clamp TechniquesProtein AggregatesProtein SubunitsCarrier ProteinsgephyrinMembrane ProteinsProtein AggregatesProtein SubunitsReceptors, GABA-ATetraspaninsaccessory proteinGABA(A) receptorGARLHgephyrininterneuronLHFPL3LHFPL4 knockoutmIPSCneuroliginplasticity

Identifiers

PMID28978485
PMCPMC5640807
OpenAlexW2762313204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.