Evidence map›Paper›PMID 28978470›Full record

ArticleCell reports2017

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.

Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J Selden, Angela M Jarrett, Anna G Sorace, Thomas E Yankeelov, Adrian Liston, Lauren I R Ehrlich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Thymus and autoimmunity.Seminars in immunopathology · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Zicheng HuDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Yu LiDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Annemarie Van NieuwenhuijzeTranslational Immunology Laboratory, VIB, Leuven 3000, Belgium; Department of Microbiology and Immunology, University of Leuven, Leuven 3000, Belgium.
Hilary J SeldenDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Angela M JarrettDepartments of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Anna G SoraceDepartments of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Diagnostic Medicine, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Thomas E YankeelovDepartments of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Diagnostic Medicine, The University of Texas at Austin, Austin, TX 78712, USA; Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Adrian ListonTranslational Immunology Laboratory, VIB, Leuven 3000, Belgium; Department of Microbiology and Immunology, University of Leuven, Leuven 3000, Belgium.
Lauren I R EhrlichDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: lehrlich@austin.utexas.edu.
The University of Texas at Austin · USKU Leuven · BEVIB-KU Leuven Center for Cancer Biology · BE

Funding

The contribution of GPCRs to thymocyte medullary entry and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Lauren Ilyse Richie EHRLICH · 2014 to 2026
$7.6M
NIAID NIH HHS R01 AI104870
6 · The paper itself

Abstract

Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contribution of CCR7 to intrathymic Treg generation. Ccr7

Indexed as

Immune ToleranceAnimalsApoptosisBone Marrow TransplantationCell DifferentiationCell SurvivalDendritic CellsGene Expression RegulationLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR7Receptors, ImmunologicSignal TransductionThymocytesCcr7 protein, mouseReceptors, CCR7Receptors, ImmunologicSirpa protein, mouseCCR7central tolerancechemokine receptordendritic cellsregulatory T cellsthymocyte developmentthymus

Identifiers

PMID28978470
PMCPMC5639943
OpenAlexW2761998451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.