ArticleBiophysical journal2017
Analysis of Claims that the Brain Extracellular Impedance Is High and Non-resistive.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Reactive EEG Biomarkers for Diagnosis and Prognosis of Alzheimer's Disease and Mild Cognitive Impairment.Biosensors & bioelectronics · 2025Article
- Simulating epileptic seizures using the bidomain model.Scientific reports · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Extracellular and intracellular components of the impedance of neural tissue.Biophysical journal · 2022Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- Brain Waves: Emergence of Localized, Persistent, Weakly Evanescent Cortical Loops.Journal of cognitive neuroscience · 2020Article
- Is the Extracellular Impedance High and Non-resistive in Cerebral Cortex?Biophysical journal · 2017Article
- Universal theory of brain waves: from linear loops to nonlinear synchronized spiking and collective brain rhythms.Physical review researchArticle
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous measurements in the brain of the impedance between two extracellular electrodes have shown that it is approximately resistive in the range of biological interest, <10 kHz, and has a value close to that expected from the conductivity of physiological saline and the extracellular volume fraction in brain tissue. Recent work from Gomes et al. has claimed that the impedance of the extracellular space is some three orders of magnitude greater than these values and also displays a 1/f frequency dependence (above a low-frequency corner frequency). Their measurements were performed between an intracellular electrode and an extracellular electrode. It is argued that they incorrectly extracted the extracellular impedance because of an inaccurate representation of the large confounding impedance of the neuronal membrane. In conclusion, no compelling evidence has been provided to undermine the well-established and physically plausible consensus that the brain extracellular impedance is low and approximately resistive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.