Evidence map›Paper›PMID 28978442›Full record

ArticleBiophysical journal2017

Mechanisms Responsible for ω-Pore Currents in Ca

Stefania Monteleone, Andreas Lieb, Alexandra Pinggera, Giulia Negro, Julian E Fuchs, Florian Hofer, Jörg Striessnig, Petronel Tuluc, Klaus R Liedl

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026
    Review
  2. Identification of novel functional sites in the CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Periodic paralysis.Handbook of clinical neurology · 2024
    Review
  4. Article
  5. Article
  6. CACNA1D-Related Channelopathies: From Hypertension to Autism.Handbook of experimental pharmacology · 2023
    Review
  7. Article
  8. Article
  9. Voltage-Gated CaFrontiers in synaptic neuroscience · 2021
    Review
  10. Article
  11. De novo CACNA1D CaPflugers Archiv : European journal of physiology · 2020
    Review
  12. Review
  13. NaScientific reports · 2018
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Stefania MonteleoneInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Andreas LiebDepartment of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria; Institute of Neurology, University College London, London, United Kingdom.
Alexandra PinggeraDepartment of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Giulia NegroDepartment of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.
Julian E FuchsInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Florian HoferInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Jörg StriessnigDepartment of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.
Petronel TulucDepartment of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria. Electronic address: petronel.tuluc@uibk.ac.at.
Klaus R LiedlInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria. Electronic address: klaus.liedl@uibk.ac.at.
Universität Innsbruck · ATMRC Laboratory of Molecular Biology · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in Ca

Indexed as

AdenomaAnimalsCalcium Channels, L-TypeComputer SimulationHEK293 CellsHumansHypokalemic Periodic ParalysisMembrane PotentialsModels, MolecularMutationProtein DomainsProtein Structure, SecondaryRabbitsStructural Homology, ProteinWaterCalcium Channels, L-TypeWater

Identifiers

PMID28978442
PMCPMC5627182
OpenAlexW2763748811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.