ArticleBiophysical journal2017
pH Dependence of Charge Multipole Moments in Proteins.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Anisotropic Electrostatics in the Instability of GLP‑1 Analog Micelles: Effects of Electrolytes, Denaturants, pH, and Temperature.ACS omega · 2026Article
- The Effects of pH on Orientations of Adsorbed Lysozyme on Negatively Charged Surfaces.The journal of physical chemistry. B · 2026Article
- Exploration of Natural Protein-Polysaccharide-Polyphenol Ternary Complexes from Grape Pomace for Clean-Label Pickering Emulsions Through pH Adjustment.Foods (Basel, Switzerland) · 2026Article
- Sericin-coated MnOScientific reports · 2025Article
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Anisotropic DLVO-like interaction for charge patchiness in colloids and proteins.Nature communications · 2025Article
- Patchy Charge Distribution Affects the pH in Protein Solutions during Dialysis.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Using Commercial Bio-Functional Fungal Polysaccharides to Construct Emulsion Systems by Associating with SPI.Foods (Basel, Switzerland) · 2025Article
- Increased preference for lysine over arginine in spike proteins of SARS-CoV-2 BA.2.86 variant and its daughter lineages.PloS one · 2025Article
- Correlation between positron annihilation lifetime and photoluminescence measurements for calcined Hydroxyapatite.Scientific reports · 2024Article
- Changes in total charge on spike protein of SARS-CoV-2 in emerging lineages.Bioinformatics advances · 2024Article
- Liquid-liquid phase separation driven by charge heterogeneity.Communications physics · 2024Article
- Interaction of Polyanionic and Polycationic Brushes with Globular Proteins and Protein-like Nanocolloids.Biomimetics (Basel, Switzerland) · 2023Review
- Conformational and Structural Changes in Chickpea Proteins Caused by Simulated Salivary Alterations in the Elderly.Foods (Basel, Switzerland) · 2023Article
- Integration of Cypoviruses into polyhedrin matrix.Nanoscale advances · 2023Article
- Langmuir monolayer of lysozyme at variable subphase pH conditions: a comprehensive study on structure, morphology and hysteresis behaviour.RSC advances · 2023Article
- Review
- Evolutionary changes in the number of dissociable amino acids on spike proteins and nucleoproteins of SARS-CoV-2 variants.Virus evolution · 2023Article
- A Universal Eluent System for Method Scouting and Separation of Biotherapeutic Proteins by Ion-Exchange, Size-Exclusion, and Hydrophobic Interaction Chromatography.Analytical chemistry · 2022Article
- Packing and trimer-to-dimer protein reconstruction in icosahedral viral shells with a single type of symmetrical structural unit.Nanoscale advances · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the changes in the environment-most notably, the pH of the surrounding solution. We study the effects of pH on the charge of four globular proteins by expanding their surface charge distributions in terms of multipoles. The detailed representation of the charges on the proteins is in this way replaced by the magnitudes and orientations of the multipole moments of varying order. Focusing on the three lowest-order multipoles-the total charge, dipole, and quadrupole moment-we show that the value of pH influences not only their magnitudes, but more notably and importantly also the spatial orientation of their principal axes. Our findings imply important consequences for the study of protein-protein interactions and the assembly of both proteinaceous shells and patchy colloids with dissociable charge groups.
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