Trial reportTrials2017
Central venous Access device SeCurement And Dressing Effectiveness for peripherally inserted central catheters in adult acute hospital patients (CASCADE): a pilot randomised controlled trial.
Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06770374 (Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients: Randomised Clinical Trial
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Development of central venous access device-associated skin impairment assessment instrument.Nursing open · 2022Pooled it
- Pooled it
- Clinical benefit of adding cyanoacrylate glue during PICC line insertion compared to standard procedure in outpatient cancer patients: Results from the randomized prospective trial PICCandGLUE.The journal of vascular access · 2026Trial
- Effects of Peripherally Inserted Central Catheter (PICC) Catheterization Nursing on Bloodstream Infection in Peripheral Central Venous Catheters in Lung Cancer: A Single-Center, Retrospective Study.Computational and mathematical methods in medicine · 2022Trial
- Feasibility study on the effect and complications of intravenous therapy nursing intervention on patients with PICC catheterization.Medicine · 2026Article
- Interpretable machine-learning risk prediction of unplanned extubation among cancer patients with peripherally inserted central catheters.Scientific reports · 2026Article
- Determining the Effectiveness of Preventive Measures in Reducing Intravenous Injection and Catheter-Related Infections: A Meta-Analysis.Iranian journal of public health · 2025Review
- Article
- The use of procedural kits may reduce unscheduled central line dressing changes: A matched pre-post intervention study.Journal of infection prevention · 2024Article
- Central venous access device terminologies, complications, and reason for removal in oncology: a scoping review.BMC cancer · 2024Article
- Risk Factors and Predictive Models for Peripherally Inserted Central Catheter Unplanned Extubation in Patients With Cancer: Prospective, Machine Learning Study.Journal of medical Internet research · 2023Article
- Prevention and treatment of catheter-related venous thrombosis in long-term parenteral nutrition: A SINuC position statement.Frontiers in nutrition · 2023Review
- Prevention of medical adhesive-related skin injury during patient care: A scoping review.International journal of nursing studies advances · 2022Article
- A Primer and Literature Review on Internal and External Retention Mechanisms for Catheter Fixation.Cureus · 2022Review
- International recommendations for a vascular access minimum dataset: a Delphi consensus-building study.BMJ quality & safety · 2021Article
- Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae.Intensive care medicine experimental · 2021Article
- In vitro testing of cyanoacrylate tissue adhesives and sutures for extracorporeal membrane oxygenation cannula securement.Intensive care medicine experimental · 2021Article
- Analysis of complications associated with peripherally inserted central venous catheters. Prospective observational study.Revista CuidarteArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeripherally inserted central catheters (PICCs) are commonly used for delivering intravenous therapy. PICC failure is unacceptably high (up to 40%) due to mechanical, infectious and thrombotic complications. Poor securement potentiates all complication types. This randomised controlled trial (RCT) aimed to examine the feasibility of a large RCT of four dressing and securement methods to prevent PICC failure.
methodsThis single-centre pilot RCT included 124 admitted medical/surgical/cancer patients aged ≥ 16 years with a PICC. Interventions were: (i) standard polyurethane dressing and sutureless securement device (SPU + SSD, control); (ii) polyurethane with absorbent lattice pad dressing (PAL + Tape); (iii) combination securement-dressing (CSD); and (iv) tissue adhesive (TA + SPU). All groups except TA + SPU had a chlorhexidine-gluconate (CHG) impregnated disc. Feasibility outcomes were recruitment and safety/acceptability of the interventions. The primary outcome was PICC failure, a composite of PICC removal for local infection, catheter-associated bloodstream infection, dislodgement, occlusion, and/or catheter fracture. Secondary outcomes included individual complications, dressing failure and dwell time, PICC dwell time, skin complications/phlebitis indicators, product costs, and patient and staff satisfaction. Qualitative feedback was also collected.
resultsPICC failure incidence was: PAL + CHG + Tape (1/5; 20%; 17.4/1000 days), SPU + SSD + CHG (control) (4/39; 10%; 9.0/1000 days), TA + SPU (3/35; 9%; 9.6/1000 days), and CSD + CHG (3/42; 7%; 9.4/1000 days). Recruitment to PAL + CHG + Tape was ceased after five participants due to concerns of PICC dislodgement when removing the dressing. CSD + CHG, TA + SPU (TA applied only at PICC insertion time), and control treatments were acceptable to patients and health professionals.
conclusionA large RCT of CSD + CHG and TA + SPU (but not PAL + CHG + Tape) versus standard care is feasible.
trial registrationAustralian and New Zealand Clinical Trials Registry, ACTRN12616000027415 . Registered on 15 January 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.