Evidence map›Paper›PMID 28978331›Full record

ArticleMicrobiome2017

Communicating the promise, risks, and ethics of large-scale, open space microbiome and metagenome research.

Daria Shamarina, Iana Stoyantcheva, Christopher E Mason, Kyle Bibby, Eran Elhaik

Abstract readLetter
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. It's a Long Way to the Tap: Microbiome and DNA-Based Omics at the Core of Drinking Water Quality.International journal of environmental research and public health · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Forensic Applications of Microbiomics: A Review.Frontiers in microbiology · 2020
    Review
  15. Next-Generation Sequencing Strategies.Cold Spring Harbor perspectives in medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daria ShamarinaDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK.
Iana StoyantchevaDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
Kyle BibbyUniversity of Notre Dame Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dameᅟ, IN, 46556, USA.
Eran ElhaikDepartment of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK. e.elhaik@sheffield.ac.uk.ORCID 0000-0003-4795-1084

Funding

Study of Neural Tube Defects Etiology: Genome and ExposomeR01ES021006 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H., MASON, CHRISTOPHER EDWARD · 2012 to 2014
$1.0M
Community Research Education and Engagement for Data Science (CREEDS)R25EB020393 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLAUDIO, LUZ, KOVATCH, PATRICIA · 2015 to 2017
$578k
NIBIB NIH HHS R25 EB020393NIEHS NIH HHS R01 ES021006
6 · The paper itself

Abstract

The public commonly associates microorganisms with pathogens. This suspicion of microorganisms is understandable, as historically microorganisms have killed more humans than any other agent while remaining largely unknown until the late seventeenth century with the works of van Leeuwenhoek and Kircher. Despite our improved understanding regarding microorganisms, the general public are apt to think of diseases rather than of the majority of harmless or beneficial species that inhabit our bodies and the built and natural environment. As long as microbiome research was confined to labs, the public's exposure to microbiology was limited. The recent launch of global microbiome surveys, such as the Earth Microbiome Project and MetaSUB (Metagenomics and Metadesign of Subways and Urban Biomes) project, has raised ethical, financial, feasibility, and sustainability concerns as to the public's level of understanding and potential reaction to the findings, which, done improperly, risk negative implications for ongoing and future investigations, but done correctly, can facilitate a new vision of "smart cities." To facilitate improved future research, we describe here the major concerns that our discussions with ethics committees, community leaders, and government officials have raised, and we expound on how to address them. We further discuss ethical considerations of microbiome surveys and provide practical recommendations for public engagement.

Indexed as

Ethics, ResearchMetagenomeMicrobiotaPublic RelationsResearchEnvironment DesignHumansMetagenomicsPublic OpinionBuilt environmentConcernsEthicsMetagenomeMetaSUBMicrobiomePublic

Identifiers

PMID28978331
PMCPMC5628477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.