ArticleBrain connectivity2017
The Hippocampus and Amygdala Are Integrators of Neocortical Influence: A CorticoCortical Evoked Potential Study.
Article in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Semiology of seizures with temporo-polar or "medio-lateral" temporal origin: A systematic review.Epileptic disorders : international epilepsy journal with videotape · 2025Pooled it
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Amygdala and Insula Connectivity Changes Following Psychotherapy for Posttraumatic Stress Disorder: A Randomized Clinical Trial.Biological psychiatry · 2021Trial
- Review
- Directed cortico-limbic dialogue in the human brain.Nature communications · 2026Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Coupling of Sharp Wave Events between Zebrafish Hippocampal and Amygdala Homologs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TMS provokes target-dependent intracranial rhythms across human cortical and subcortical sites.bioRxiv : the preprint server for biology · 2023Article
- Quantitative approaches to guide epilepsy surgery from intracranial EEG.Brain : a journal of neurology · 2023Article
- Closed-loop enhancement and neural decoding of cognitive control in humans.Nature biomedical engineering · 2023Article
- Stimulating native seizures with neural resonance: a new approach to localize the seizure onset zone.Brain : a journal of neurology · 2022Article
- Inducing neuroplasticity through intracranial θ-burst stimulation in the human sensorimotor cortex.Journal of neurophysiology · 2021Article
- Article
- Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region.Human brain mapping · 2021Article
- Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis.Quantitative imaging in medicine and surgery · 2021Article
- Sex-specific signatures of intrinsic hippocampal networks and regional integrity underlying cognitive status in multiple sclerosis.Brain communications · 2021Article
- Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease.Frontiers in aging neuroscience · 2021Article
- Crossmodal Phase Reset and Evoked Responses Provide Complementary Mechanisms for the Influence of Visual Speech in Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials.Frontiers in neurology · 2020Article
- Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Brain stimulation is increasingly viewed as an effective approach to treat neuropsychiatric disease. The brain's organization in distributed networks suggests that the activity of a remote brain structure could be modulated by stimulating cortical areas that strongly connect to the target. Most connections between cerebral areas are asymmetric, and a better understanding of the relative direction of information flow along connections could improve the targeting of stimulation to influence deep brain structures. The hippocampus and amygdala, two deep-situated structures that are crucial to memory and emotions, respectively, have been implicated in multiple neurological and psychiatric disorders. We explored the directed connectivity between the hippocampus and amygdala and the cerebral cortex in patients implanted with intracranial electrodes using corticocortical evoked potentials (CCEPs) evoked by single-pulse electrical stimulation. The hippocampus and amygdala were connected with most of the cortical mantle, either directly or indirectly, with the inferior temporal cortex being most directly connected. Because CCEPs assess the directionality of connections, we could determine that incoming connections from cortex to hippocampus were more direct than outgoing connections from hippocampus to cortex. We found a similar, although smaller, tendency for connections between the amygdala and cortex. Our results support the roles of the hippocampus and amygdala to be integrators of widespread cortical influence. These results can inform the targeting of noninvasive neurostimulation to influence hippocampus and amygdala function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.