ArticleOncotarget2017
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.Aging · 2021Pooled it
- The Role of miR-138 in Cardiovascular Diseases.BioMed research international · 2025Review
- Hydrogen peroxide and cisplatin regulate the ROS/PKM2 pathway to affect the growth of cancer.American journal of cancer research · 2025Article
- Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway.Frontiers in oncology · 2024Article
- Immunohistochemical detection of MnSOD in colon adenocarcinoma patients - clinical application.Przeglad gastroenterologiczny · 2024Article
- Article
- The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer.Theranostics · 2023Review
- Identification of Prognostic Markers for Head and NeckSquamous Cell Carcinoma Based on Glycolysis-Related Genes.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma.Oncology letters · 2021Article
- High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma.Antioxidants (Basel, Switzerland) · 2021Article
- High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma.Journal of Cancer · 2020Article
- Pyruvate kinase M2: A simple molecule with complex functions.Free radical biology & medicine · 2019Review
- Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.Journal of cellular and molecular medicine · 2019Article
- Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Wiley interdisciplinary reviews. RNA · 2018Review
- Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer.Oncotarget · 2018Article
- High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Pyruvate kinase M2 (PKM2) has been verified to correlate with the prognosis of many types of cancer. However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. The immunohistochemistry (IHC) results confirmed that PKM2 is overexpressed in patients with TSCC. PKM2 up-regulation was related to lymph node metastasis and associated with reduced overall survival. According to the microarray analysis and Western blots, PKM2 expression was up-regulated in TSCC cells with enhanced metastatic potential. PKM2 knockdown inhibited cell migration and invasion, reduced SOD2 (manganese superoxide dismutase) activity and the intracellular H
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Registered trials
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