ArticleOncotarget2017
Markers of inflammation and influence of nitric oxide on platelet activation in the course of
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- A systematic review and meta-analysis of Danshen combined with mesalazine for the treatment of ulcerative colitis.Frontiers in pharmacology · 2024Pooled it
- Kolaviron attenuates Dextran sulphate sodium-induced colitis by enhancing the expression of MUC-2.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization.Redox report : communications in free radical research · 2022Article
- Animal Models and Pathogenesis of Ulcerative Colitis.Computational and mathematical methods in medicine · 2022Article
- Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain-Intestine Axis.Biophysics · 2022Article
- Clinical significance of blood platelets and mean platelet volume in patients with ulcerative colitis.The Journal of international medical research · 2021Article
- Single Donor FMT Reverses Microbial/Immune Dysbiosis and Induces Clinical Remission in a Rat Model of Acute Colitis.Pathogens (Basel, Switzerland) · 2021Article
- Time-Dependent Indirect Antioxidative Effects of Oat Beta-Glucans on Peripheral Blood Parameters in the Animal Model of Colon Inflammation.Antioxidants (Basel, Switzerland) · 2020Article
- Systematic Investigation of the Efficacy of Sinitang Decoction Against Ulcerative Colitis.Frontiers in pharmacology · 2020Article
- Analysis of Genes Involved in Ulcerative Colitis Activity and Tumorigenesis Through Systematic Mining of Gene Co-expression Networks.Frontiers in physiology · 2019Article
- Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches.Inflammopharmacology · 2018Review
- Platelet Mass Index and Other Platelet Parameters in the Assessment of Inflammatory Bowel Diseases Activity.Current health sciences journalArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis is a non-specific inflammatory bowel disease of unknown etiology. We investigated whether severe form of ulcerative colitis may lead to increased number of platelets, changes in platelet parameters and their activation. To address our objectives, we measured concentrations of nitric oxide and markers of inflammation. We found increased number of low-volume platelets in a group of affected patients. However, their activity was not as high as expected. In addition to that we observed eight times higher concentration of nitric oxide in patients suffering from ulcerative colitis than in healthy individuals. Besides, severe form of the disease manifested itself with increased concentrations of interleukine 6, matrix metalloproteinase-9 and neopterin. Based on the results we propose that high amounts of nitric oxide inhibit platelet activation in severe form of ulcerative colitis. Moreover, our observations regarding interleukine 6, matrix metalloproteinase-9 and neopterin suggest that they may become useful markers of active form of ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.