Evidence map›Paper›PMID 28978091›Full record

ArticleOncotarget2017

Low-dose photon irradiation induces invasiveness through the SDF-1α/CXCR4 pathway in malignant mesothelioma cells.

Yoshikane Yamauchi, Seyer Safi, Lena Orschiedt, Adriane Gardyan, Stephan Brons, Juliane Rieber, Nils H Nicolay, Peter E Huber, Martin Eichhorn, Hendrik Dienemann and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yoshikane YamauchiDepartment of Thoracic Surgery, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Seyer SafiDepartment of Thoracic Surgery, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Lena OrschiedtDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Adriane GardyanDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Stephan BronsHeidelberg Ion Treatment Facility (HIT), Heidelberg, Germany.
Juliane RieberDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Nils H NicolayDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Peter E HuberDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Martin EichhornDepartment of Thoracic Surgery, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Hendrik DienemannDepartment of Thoracic Surgery, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Felix J F HerthPneumology and Critical Care Medicine, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Klaus-Josef WeberDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Hans HoffmannDepartment of Thoracic Surgery, Thorax Clinic, Heidelberg University, Heidelberg, Germany.
Stefan RiekenDepartment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DEHeidelberger Institut für Radioonkologie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-dose photon irradiation has repeatedly been suspected to increase a risk of promoting local recurrence of disease or even systemic dissemination. The purpose of this study was to investigate the motility of malignant pleural mesothelioma (MPM) cell lines after low-doses of photon irradiation and to elucidate the mechanism of the detected phenotype.

methodsH28 and H226 MPM cells were examined in clonogenic survival experiments and migration assays with and without various doses of photon and carbon ion irradiation. C-X-C chemokine receptor type 4 (CXCR4), SDF-1α, β

resultsThe migration of MPM cells was stimulated by both fetal bovine serum and by stromal cell-derived factor 1α (SDF-1α). Low doses of photon irradiation (1 Gy and 2 Gy) suppressed clonogenicity, but promoted migration of both H28 and H226 cells through the SDF-1α/CXCR4 pathway. Hypermigration was inhibited by the administration of CXCR4 antagonist, AMD3100. In contrast, corresponding doses of carbon ion irradiation (0.3 Gy and 1 Gy) suppressed clonogenicity, but did not promote MPM cell migration.

conclusionOur findings suggest that the co-administration of photon irradiation and the CXCR4-antagonist AMD3100 or the use of carbon ions instead of photons may be possible solutions to reduce the risk of locoregional tumor recurrence after radiotherapy for MPM.

Indexed as

carbon ion irradiationCXCR4mesotheliomaphoton irradiationSDF-1α

Identifiers

PMID28978091
PMCPMC5620231
OpenAlexW2735327644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.