ArticleOncotarget2017
Serum cystatin C is associated with large cerebral artery stenosis in acute ischemic stroke.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Development and validation of a dynamic nomogram for predicting in-hospital mortality in acute massive cerebral infarction: a retrospective study in a Chinese population.European journal of medical research · 2025Article
- Article
- Serum Cystatin C is Associated with Depression After Intracerebral Hemorrhage.Neuropsychiatric disease and treatment · 2023Article
- Association between serum cystatin C level and post-stroke cognitive impairment in patients with acute mild ischemic stroke.Brain and behavior · 2022Article
- Cystatin C predicts futile recanalization in patients with acute ischemic stroke after endovascular treatment.Journal of neurology · 2022Article
- Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment.Frontiers in neurology · 2022Review
- Serum cystatin C was a marker of poststroke fatigue in hypertensive intracerebral hemorrhage.Brain and behavior · 2021Article
- Expression and significance of S-100β, CysC and NF-κB in patients with acute cerebral infarction.Experimental and therapeutic medicine · 2021Article
- Association BetweenFrontiers in neurology · 2021Article
- Serum cystatin C is associated with carotid atherosclerosis in patients with acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Association between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus without Nephropathy.Diabetes & metabolism journal · 2018Article
- Serum cystatin C is associated with kidney function but not with cardiovascular risk factors or subclinical atherosclerosis in patients with Systemic Lupus Erythematosus.Clinical rheumatology · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large cerebral artery stenosis is a major cause of acute ischemic stroke (AIS); however, the correlation between serum cystatin C (CysC) and the stenosis of large cerebral arteries in patients with AIS has not been established. We performed a retrospective review of acute ischemic stroke patients, who were examined by cerebral digital subtraction angiography(DSA). Participants (252 cases) included 131 patients without stenosis and 121 patients with large cerebral artery stenosis. Serum CysC levels in patients with large cerebral artery stenosis were much higher than that of control subjects (p<0.001). However, serum CysC levels were not related to the location of stenosis. Further, logistic regression analyses showed that increased serum CysC was an independent risk factor of large cerebral artery stenosis in patients with acute ischemic stroke. Total participants were subdivided into quintiles based on serum CysC levels. Compared with the first quintile, the odds ratios of risk for large cerebral artery stenosis in the fourth and the fifth quintile were 1.26 (p<0.05) and 4.71(p<0.05) respectively, after the adjustment for age, sex, and smoking, hypertension, type 2 diabetes mellitus(DM), dyslipidemia, creatinine(Cr), urea, uric acid, and C reactive protein(CRP). Therefore, a significant positive correlation was observed between elevated serum CysC levels and large cerebral artery stenosis in patients with acute ischemic stroke. In summary, our findings provide new insights into the correlation between increased serum CysC and large cerebral artery stenosis in patients with acute ischemic stroke.
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