Evidence map›Paper›PMID 28977896›Full record

ArticleOncotarget2017

Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.

Hao Zhang, Guangchao Wang, Chen Ding, Peng Liu, Renkai Wang, Wenbin Ding, Dake Tong, Dajiang Wu, Cheng Li, Qiang Wei and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Circular RNAs Binding to RNA-Binding Proteins.Advances in experimental medicine and biology · 2025
    Review
  8. Research (Washington, D.C.) · 2025
    Article
  9. Review
  10. Review
  11. Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Article
  14. Epigenetic reprogramming in cancer: From diagnosis to treatment.Frontiers in cell and developmental biology · 2023
    Review
  15. Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma.International journal of general medicine · 2023
    Review
  16. Circular RNAs: typical biomarkers for bone-related diseases.Journal of Zhejiang University. Science. B · 2022
    Article
  17. Review
  18. Review
  19. The emerging roles of circRNAs in cancer and oncology.Nature reviews. Clinical oncology · 2022
    Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Hao ZhangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Guangchao WangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Chen DingDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Peng LiuDepartment of General Sugery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Renkai WangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wenbin DingDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Dake TongDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Dajiang WuDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Cheng LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Qiang WeiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xin ZhangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Di LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Peizhao LiuDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Haochen CuiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Hao TangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Fang JiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Changhai Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deregulated expression of circular RNA (circRNA) has been determined to be important in carcinogenesis and progression; however, in the most common type of primary malignant bone tumor osteosarcoma, the roles of circRNA in cancer development still remain to be elucidated. Here, we found that circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both

Indexed as

Bcl-2circRNAcircUBAP2miR-143osteosarcoma

Identifiers

PMID28977896
PMCPMC5617456
OpenAlexW2727451311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.