Evidence map›Paper›PMID 28977780›Full record

ArticleRadiation research2017

Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.

Sagar Bhayana, Feifei Song, Jidhin Jacob, Paolo Fadda, Nicholas C Denko, Meng Xu-Welliver, Arnab Chakravarti, Naduparambil K Jacob

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Effects of Recombinant αInternational journal of molecular sciences · 2024
    Article
  6. Biomarkers to Predict Lethal Radiation Injury to the Rat Lung.International journal of molecular sciences · 2023
    Article
  7. Transcriptomics for radiation biodosimetry: progress and challenges.International journal of radiation biology · 2023
    Review
  8. MicroRNAs as Biomarkers for Ionizing Radiation Injury.Frontiers in cell and developmental biology · 2022
    Review
  9. Article
  10. MicroRNA: a novel implication for damage and protection against ionizing radiation.Environmental science and pollution research international · 2021
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. [Value of podocalyxin levels in urinary extracellular vesicles for diagnosis of diabetic nephropathy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sagar BhayanaDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Feifei SongDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Jidhin JacobDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Paolo FaddaDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Nicholas C DenkoDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Meng Xu-WelliverDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Arnab ChakravartiDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Naduparambil K JacobDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI WANCAI YANG · 1985 to 2026
$132.3M
TUMOR HYPOXIA--MOLECULAR STUDIES &CLINICAL EXPLOITATIONP01CA067166 · NCI · STANFORD UNIVERSITY · PI DENKO, NICHOLAS C. · 1996 to 2017
$25.5M
Decreasing oxygen metabolism to redcue hypoxia and radiosensitize tumors.R01CA163581 · NCI · OHIO STATE UNIVERSITY · PI DENKO, NICHOLAS C. · 2012 to 2016
$1.7M
NCI NIH HHS P01 CA067166NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA163581
6 · The paper itself

Abstract

Radiation nephropathy is one of the common late effects in cancer survivors who received radiotherapy as well as in victims of radiation accidents. The clinical manifestations of radiation nephropathy occur months after exposure. To date, there are no known early biomarkers to predict the future development of radiation nephropathy. This study focuses on the development of urinary biomarkers providing readout of acute responses in renal tubular epithelial cells. An amplification-free hybridization-based nCounter assay was used to detect changes in mouse urinary miRNAs after irradiation. After a single LD

Indexed as

Whole-Body IrradiationAnimalsBiomarkersDose-Response Relationship, RadiationEpithelial CellsExosomesHumansKidney TubulesKidney Tubules, ProximalLethal Dose 50Leukemia, Myeloid, AcuteMice, Inbred C57BLMicroRNAsPrecursor Cell Lymphoblastic Leukemia-LymphomaRadiation InjuriesRadiation Injuries, ExperimentalBiomarkersMicroRNAsMIRN1224 microRNA, humanRNA, Neoplasm

Identifiers

PMID28977780
PMCPMC7263377
OpenAlexW2761207379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.