ReviewAnnual review of pharmacology and toxicology2018
Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.
Review in Annual review of pharmacology and toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Adipose extracellular vesicles carrying miR-210-3p drive macrophage inflammation and nicotine-induced atherosclerosis.iScience · 2026Article
- The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.Addiction neuroscience · 2025Article
- Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction.Frontiers in neuroscience · 2025Review
- Exploring core symptoms of alcohol withdrawal syndrome in alcohol use disorder patients: a network analysis approach.Frontiers in psychiatry · 2024Article
- Review
- Aging in nucleus accumbens and its impact on alcohol use disorders.Alcohol (Fayetteville, N.Y.) · 2023Review
- Behavioral studies of spinal conditioning: The spinal cord is smarter than you think it is.Journal of experimental psychology. Animal learning and cognition · 2022Article
- The serotonin 2A receptor agonist TCB-2 attenuates heavy alcohol drinking and alcohol-induced midbrain inhibitory plasticity.Addiction biology · 2022Article
- Review
- Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice.Frontiers in neuroscience · 2022Article
- Risky Behaviours of Spanish University Students: Association with Mediterranean Diet, Sexual Attitude and Chronotype.Nutrients · 2021Observational
- Chronic nicotine increases alcohol self-administration in adult male Wistar rats.Psychopharmacology · 2021Article
- Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.Neuropharmacology · 2020Review
- Learning to promote recovery after spinal cord injury.Experimental neurology · 2020Review
- Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness.Trends in neurosciences · 2018Review
- Drug-Induced Glucocorticoids and Memory for Substance Use.Trends in neurosciences · 2018Review
- Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Adolescent social stress increases anxiety-like behavior and ethanol consumption in adult male and female C57BL/6J mice.Scientific reports · 2018Article
- Practical outpatient pharmacotherapy for alcohol use disorder.Drugs in context · 2018Review
- The influence of adolescent nicotine exposure on ethanol intake and brain gene expression.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stress and tobacco smoking are risk factors for alcoholism, but the underlying neural mechanisms are not well understood. Although stress, nicotine, and alcohol have broad, individual effects in the brain, some of their actions converge onto the same mechanisms and circuits. Stress and nicotine augment alcohol-related behaviors, in part via modulation of alcohol-evoked neuronal plasticity and metaplasticity mechanisms. Stress modulates alcohol-evoked plasticity via the release of signaling molecules that influence synaptic transmission. Nicotine also activates some of the same signaling molecules, cells, and circuits, producing a convergence of both stress and nicotine onto common plasticity mechanisms that influence alcohol self-administration. We describe several forms of alcohol-induced plasticity, including classic Hebbian plasticity at glutamatergic synapses, and we highlight less appreciated forms, such as non-Hebbian and GABAergic synaptic plasticity. Risk factors such as stress and nicotine initiate lasting neural changes that modify subsequent alcohol-induced synaptic plasticity and increase the vulnerability to alcohol addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.