ReviewRheumatology (Oxford, England)2018
Marrow fat may distribute the energy of impact loading throughout subchondral bone.
Review in Rheumatology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- The association between body roundness index and osteoporosis in American adults: analysis from NHANES dataset.Frontiers in nutrition · 2024Article
- Fat and bone: the multiperspective analysis of a close relationship.Quantitative imaging in medicine and surgery · 2020Review
- Subchondral pressures and perfusion during weight bearing.Journal of orthopaedic surgery and research · 2020Article
- An in vitro model to explore subchondral perfusion and intraosseous pressure.Journal of experimental orthopaedics · 2019Article
- Intraosseous pressure during loading and with vascular occlusion in an animal model.Bone & joint research · 2018Article
- Factors affecting intraosseous pressure measurement.Journal of orthopaedic surgery and research · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most students of articular mechanics consider impact loads to be compressive forces that are borne by an intraosseous, trabecular scaffold. The possible role of marrow fat, which comprises about 75% of the structure, is generally ignored, and the potential contribution of type 1 collagen, the prototypic tensile protein, is not considered. Here, I question the evidence underlying these omissions and reject the conclusion of exclusive trabecular compression. Instead, I suggest that impact loading pressurizes the fat in subchondral compartments, and those pressures stretch the elastic trabecular walls, which are thereby subjected to tensile loading. The load-driven pressure pulses then diminish as they pass from each compartment to its adjoining neighbours. The resulting pressure gradient distributes the burden throughout the subchondrium, stores energy for ensuing recovery and subjects individual trabeculae only to the net pressure differences between adjacent compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.