ArticleThe international journal of neuropsychopharmacology2017
Intranasal Oxytocin following Uncontrollable Stress Blocks Impairments in Hippocampal Plasticity and Recognition Memory in Stressed Rats.
Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress.Experimental neurobiology · 2023Article
- Chemogenetic modulation of the medial prefrontal cortex regulates resistance to acute stress-induced cognitive impairments.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents.Frontiers in cellular neuroscience · 2023Review
- Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer's Disease: Interplay of ERK1/2/GSK3β/Caspase-3.Neurochemical research · 2022Article
- Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.Scientific reports · 2022Article
- Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin.Frontiers in psychiatry · 2022Article
- Environmental influences on the pace of brain development.Nature reviews. Neuroscience · 2021Review
- Oxytocin Reduces Brain Injury and Maintains Blood-Brain Barrier Integrity After Ischemic Stroke in Mice.Neuromolecular medicine · 2020Article
- Oxytocin Differentiated Effects According to the Administration Route in a Prenatal Valproic Acid-Induced Rat Model of Autism.Medicina (Kaunas, Lithuania) · 2020Article
- Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice.Frontiers in endocrinology · 2020Article
- Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats.Neuropharmacology · 2019Article
- Pair-housing rats does not protect from behavioral consequences of an acute traumatic experience.Behavioral neuroscience · 2019Article
- BK channel blocker paxilline attenuates thalidomide-caused synaptic and cognitive dysfunctions in mice.Scientific reports · 2018Article
- Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders.Frontiers in synaptic neuroscience · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nasal pretreatment with the neuropeptide oxytocin has been reported to prevent stress-induced impairments in hippocampal synaptic plasticity and spatial memory in rats. However, no study has asked if oxytocin application following a stress experience is effective in rescuing stress-induced impairments. Methods: Synaptic plasticity was measured in hippocampal Schaffer collateral-CA1 synapses of rats subjected to uncontrollable stress; their cognitive function was examined using an object recognition task. Results: Impaired induction of long-lasting, long-term potentiation by uncontrollable stress was rescued, as demonstrated both in rats and hippocampal slices. Intranasal oxytocin after experiencing uncontrollable stress blocked cognitive impairments in stressed rats and in stressed hippocampal slices treated with a perfused bath solution containing oxytocin. Conclusions: These results indicated that posttreatment with oxytocin after experiencing a stressful event can keep synaptic plasticity and cognition function intact, indicating the therapeutic potential of oxytocin for stress-related disorders, including posttraumatic stress disorder.
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Registered trials
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