Evidence map›Paper›PMID 28977499›Full record

ArticleNucleic acids research2017

Addressable configurations of DNA nanostructures for rewritable memory.

Arun Richard Chandrasekaran, Oksana Levchenko, Dhruv S Patel, Molly MacIsaac, Ken Halvorsen

Abstract read
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Light-responsive DNA nanostructures.Nature reviews. Chemistry · 2026
    Review
  2. Article
  3. Article
  4. Multiplexed and high-bandwidth DNA computing circuits with superresolution DNA origami displays.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Processing DNA Storage through Programmable Assembly in a Droplet-Based Fluidics System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Parallel molecular computation on digital data stored in DNA.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Self-Assembly of DNA Nanostructures in Different Cations.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  15. Article
  16. Article
  17. Self-assembly of DNA nanostructures in different cations.bioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Oksana LevchenkoThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Dhruv S PatelThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Molly MacIsaacThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
NIGMS NIH HHS R35 GM124720
6 · The paper itself

Abstract

DNA serves as nature's information storage molecule, and has been the primary focus of engineered systems for biological computing and data storage. Here we combine recent efforts in DNA self-assembly and toehold-mediated strand displacement to develop a rewritable multi-bit DNA memory system. The system operates by encoding information in distinct and reversible conformations of a DNA nanoswitch and decoding by gel electrophoresis. We demonstrate a 5-bit system capable of writing, erasing, and rewriting binary representations of alphanumeric symbols, as well as compatibility with 'OR' and 'AND' logic operations. Our strategy is simple to implement, requiring only a single mixing step at room temperature for each operation and standard gel electrophoresis to read the data. We envision such systems could find use in covert product labeling and barcoding, as well as secure messaging and authentication when combined with previously developed encryption strategies. Ultimately, this type of memory has exciting potential in biomedical sciences as data storage can be coupled to sensing of biological molecules.

Indexed as

Computers, MolecularBacteriophage M13DNA, ViralElectrophoresis, Agar GelInformation Storage and RetrievalNanostructuresReproducibility of ResultsDNA, Viral

Identifiers

PMID28977499
PMCPMC5737491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.