ReviewHuman molecular genetics2017
Between form and function: the complexity of genome folding.
Review in Human molecular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- JMnorm: a novel joint multi-feature normalization method for integrative and comparative epigenomics.Nucleic acids research · 2024Article
- Snapshot: a package for clustering and visualizing epigenetic history during cell differentiation.BMC bioinformatics · 2023Article
- CLIMB: High-dimensional association detection in large scale genomic data.Nature communications · 2022Article
- Review
- Dynamics of the 4D genome during in vivo lineage specification and differentiation.Nature communications · 2020Article
- S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data.Nucleic acids research · 2020Article
- An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.Genome research · 2020Article
- The transformation of medical genetics by clinical genomics: hubris meets humility.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such folding on nuclear processes remain topics of intensive current research. A longstanding, unanswered question is whether nuclear organization is simply a reflection of nuclear processes such as transcription and replication, or whether chromatin is folded by independent mechanisms and this per se encodes function? Evidence is emerging that both may be true. Here, using the α-globin gene cluster as an illustrative model, we provide an overview of the most recent insights into the layers of genome organization across different scales and how this relates to gene activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.