ArticleNucleic acids research2017
Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- 3D chromatin organisation contributes to the regulatory logic in differentiating lymphatic endothelium.EMBO reports · 2026Article
- Article
- Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.The Journal of experimental medicine · 2024Article
- Article
- Three-dimensional genome structure and function.MedComm · 2023Review
- Three-dimensional genome organization in immune cell fate and function.Nature reviews. Immunology · 2023Review
- The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases.Cell regeneration (London, England) · 2022Review
- Topoisomerase 2β and DNA topology during B cell development.Frontiers in immunology · 2022Article
- Hierarchical chromatin features reveal the toxin production in Bungarus multicinctus.Chinese medicine · 2021Article
- Spatial Organization of Chromatin: Transcriptional Control of Adaptive Immune Cell Development.Frontiers in immunology · 2021Review
- Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies.Frontiers in immunology · 2021Review
- Major Reorganization of Chromosome Conformation During Muscle Development in Pig.Frontiers in genetics · 2021Article
- Biased visibility in Hi-C datasets marks dynamically regulated condensed and decondensed chromatin states genome-wide.BMC genomics · 2020Article
- Epigenetic dynamics in normal and malignant B cells: die a hero or live to become a villain.Current opinion in immunology · 2019Review
- Analyzing the 3D chromatin organization coordinating with gene expression regulation in B-cell lymphoma.BMC medical genomics · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome organization in 3D nuclear-space is important for regulation of gene expression. However, the alterations of chromatin architecture that impinge on the B cell-fate choice of multi-potent progenitors are still unclear. By integrating in situ Hi-C analyses with epigenetic landscapes and genome-wide expression profiles, we tracked the changes in genome architecture as the cells transit from a progenitor to a committed state. We identified the genomic loci that undergo developmental switch between A and B compartments during B-cell fate determination. Furthermore, although, topologically associating domains (TADs) are stable, a significant number of TADs display structural alterations that are associated with changes in cis-regulatory interaction landscape. Finally, we demonstrate the potential roles for Ebf1 and its downstream factor, Pax5, in chromatin reorganization and transcription regulation. Collectively, our studies provide a general paradigm of the dynamic relationship between chromatin reorganization and lineage-specific gene expression pattern that dictates cell-fate determination.
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