Evidence map›Paper›PMID 28977347›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Nutritional Supplementation With Physical Activity Improves Muscle Composition in Mobility-Limited Older Adults, The VIVE2 Study: A Randomized, Double-Blind, Placebo-Controlled Trial.

Davis A Englund, Dylan R Kirn, Afsaneh Koochek, Hao Zhu, Thomas G Travison, Kieran F Reid, Åsa von Berens, Michael Melin, Tommy Cederholm, Thomas Gustafsson and 1 more

Erratum issued Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01542892 (Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability), which is not on this map. Cited by 78 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01542892 nacompletednot on this map

Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability (The VIVE2 Study)

TypeinterventionalSponsorTufts UniversityRan2011 to 2014Enrolled150ConditionsSarcopeniaArmsExercise Intervention, Supplement Intervention
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  10. Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Davis A EnglundNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Dylan R KirnNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Afsaneh KoochekClinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden.
Hao ZhuInstitute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Thomas G TravisonInstitute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Kieran F ReidNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Åsa von BerensClinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden.
Michael MelinDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Tommy CederholmClinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden.
Thomas GustafssonDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Roger A FieldingNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNutritional supplementation and physical activity have been shown to positively influence muscle mass and strength in older adults. The efficacy of long-term nutritional supplementation in combination with physical activity in older adults remains unclear.

methodsMobility-limited (short physical performance battery [SPPB] ≤9) and vitamin D insufficient (serum 25(OH) D 9-24 ng/mL) older adults were recruited for this study. All subjects participated in a physical activity program. Subjects were randomized to consume a daily nutritional supplement (150 kcal, 20 g whey protein, 800 IU vitamin D, 119 mL beverage) or placebo (30 kcal, nonnutritive, 119 mL). In a prespecified secondary analysis, we examined total-body composition (dual energy X-ray absorptiometry), thigh composition (computed tomography), and muscle strength, power, and quality before and after the 6-month intervention.

resultsOne hundred and forty-nine subjects were randomized into the study [mean (standard deviation, SD) age 78.5 (5.4) years; 46.3% female; mean (SD) short physical performance battery 7.9 (1.2); mean (SD) vitamin D 18.7 (6.4) ng/mL]. After the intervention period both groups demonstrated improvements in muscle strength, body composition, and thigh composition. Nutritional supplementation lead to further losses of intermuscular fat (p = .049) and increased normal muscle density (p = .018).

conclusionsSix months of physical activity resulted in improvements in body composition, subcutaneous fat, intermuscular fat, and strength measures. The addition of nutritional supplementation resulted in further declines in intermuscular fat and improved muscle density compared to placebo. These results suggest nutritional supplementation provides additional benefits to mobility-limited older adults undergoing exercise training. ClinicalTrials.gov Identifier: NCT01542892.

Indexed as

Dietary SupplementsMobility LimitationAbsorptiometry, PhotonAgedDietary ProteinsDouble-Blind MethodEnergy IntakeExerciseFemaleHumansMaleMuscle, SkeletalMuscle StrengthPatient ComplianceResistance TrainingSarcopeniaDietary ProteinsElderlyExerciseProteinSarcopeniaVitamin D

Identifiers

PMID28977347
PMCPMC6555188

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.