ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Mitochondrial dysfunction in the regulation of aging and aging-related diseases.Cell communication and signaling : CCS · 2025Review
- Hypoxia as a medicine.Science translational medicine · 2025Review
- Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.Cardiovascular diabetology · 2025Review
- GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The Hunger Games as the Key to Happily Ever After?The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- The ups and downs of caloric restriction and fasting: from molecular effects to clinical application.EMBO molecular medicine · 2022Review
- Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.Nature metabolism · 2021Article
- The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models.Nutrients · 2021Review
- Intermittent fasting: from calories to time restriction.GeroScience · 2021Review
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome.Frontiers in behavioral neuroscience · 2021Article
- Nicotinamide Riboside Neutralizes Hypothalamic Inflammation and Increases Weight Loss Without Altering Muscle Mass in Obese Rats Under Calorie Restriction: A Preliminary Investigation.Frontiers in nutrition · 2021Article
- Moonshots for aging.Nutrition and healthy aging · 2020Review
- The Influence of Feed and Drinking Water on Terrestrial Animal Research and Study Replicability.ILAR journal · 2020Article
- Therapeutic Time-restricted Feeding Reduces Renal Tumor Bioluminescence in Mice but Fails to Improve Anti-CTLA-4 Efficacy.Anticancer research · 2020Article
- Article
- Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.Nutrients · 2020Review
- Does Diet Have a Role in the Treatment of Alzheimer's Disease?Frontiers in aging neuroscience · 2020Review
- Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys.JCI insight · 2019Article
- Longevity: Lesson from Model Organisms.Genes · 2019Review
Corrections and comments
- Commented on by
- Erratum issuedErratum.2017
Authors and funding
6 authors.
Funding
Abstract
For a century, we have known that caloric restriction influences aging in many species. However, only recently it was firmly established that the effect is not entirely dependent on the calories provided. Instead, rodent and nonhuman primate models have shown that the rate of aging depends on other variables, including the macronutrient composition of the diet, the amount of time spent in the restricted state, age of onset, the gender and genetic background, and the particular feeding protocol for the control group. The field is further complicated when attempts are made to compare studies across different laboratories, which seemingly contradict each other. Here, we argue that some of the contradictory findings are most likely due to methodological differences. This review focuses on the four methodological differences identified in a recent comparative report from the National Institute on Aging and University of Wisconsin nonhuman primate studies, namely feeding regimen, diet composition, age of onset, and genetics. These factors, that may be influencing the effects of a calorie restriction intervention, are highlighted in the rodent model to draw parallels and elucidate findings reported in a higher species, nonhuman primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.