ArticleRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
USE OF WARFARIN IN PEDIATRICS: CLINICAL AND PHARMACOLOGICAL CHARACTERISTICS.
Article in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development of an isavuconazole physiologically-based pharmacokinetic model for adult and pediatric populations.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Short Stature in Moyamoya Disease: A Systematic Review of Potential Mechanisms and Clinical Outcomes.Stroke research and treatment · 2025Review
- Getting the OK to Import Zero K MVI: Maintaining TTR in an Infant with SBS.Digestive diseases and sciences · 2020Article
- Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets.Pharmaceutics · 2019Article
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3 authors.
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Abstract
objectiveTo describe how children respond to oral anticoagulation with warfarin, verifying the influence of age, clinical condition, route of administration of warfarin and use of total parenteral nutrition (TPN), as well as to describe risk factors for the occurrence of thrombotic events (TE) in childhood.
methodsA retrospective descriptive study including all patients ≤18 years old for whom warfarin was prescribed in a university hospital. Patients were divided according to clinical condition, age, route of medication administration and use of TPN. Data was collected from the patients' medical records and the analysis considered the risk factors for TE already described in the literature, the time and the dose required in order to reach the first International Normalized Ratio (INR) in the target and the adverse events in this period. After reaching the INR, the maintenance of anticoagulation was verified by the prescribed dose and INR tests.
resultsTwenty-nine patients were included in the study. The major risk factor for TE was the use of a central venous catheter in 89.6% of the patients. Patients with short bowel syndrome and total parenteral nutrition required significantly higher doses (p≤0.05) to achieve and maintain the INR in the target. Patients ≤1 year old needed longer periods and required an increased dose of anticoagulation and maintenance than older patients. The mean number of INR examinations below the target was 48.2% in the groups studied.
conclusionsThe observed complexity of anticoagulant therapy reinforces the need to develop protocols that guide clinical practice.
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