ArticlePloS one2017
Differential toxicity and venom gland gene expression in Centruroides vittatus.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Paralysis efficiency (PDToxicon: X · 2026Article
- Intersexual Differences in the Gene Expression ofToxins · 2023Article
- Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail.Nature communications · 2023Article
- The Enzymatic Core of Scorpion Venoms.Toxins · 2022Article
- Intraspecific differences inEXCLI journal · 2022Article
- Reduced Toxicity ofToxins · 2021Article
- An integrated transcriptomic and proteomic approach to identify the main Torymus sinensis venom components.Scientific reports · 2021Article
- Armed stem to stinger: a review of the ecological roles of scorpion weapons.The journal of venomous animals and toxins including tropical diseases · 2021Review
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation in venom toxicity and composition exists in many species. In this study, venom potency and venom gland gene expression was evaluated in Centruroides vittatus, size class I-II (immature) and size class IV (adults/penultimate instars) size classes. Venom toxicity was evaluated by probit analysis and returned ED50 values of 50.1 μg/g for class IV compared to 134.2 μg/g for class I-II 24 hours post injection, suggesting size class IV was 2.7 fold more potent. Next generation sequencing (NGS and qPCR were used to characterize venom gland gene expression. NGS data was assembled into 36,795 contigs, and annotated using BLASTx with UNIPROT. EdgeR analysis of the sequences showed statistically significant differential expression in transcripts associated with sodium and potassium channel modulation. Sodium channel modulator expression generally favored size class IV; in contrast, potassium channel modulators were favored in size class I-II expression. Real-time quantitative PCR of 14 venom toxin transcripts detected relative expression ratios that paralleled NGS data and identified potential family members or splice variants for several sodium channel modulators. Our data suggests ontogenetic differences in venom potency and venom related genes expression exist between size classes I-II and IV.
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