Evidence map›Paper›PMID 28976744›Full record

ArticleJournal of the American Chemical Society2017

Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation.

Yintao Sun, Alexander L Wollenberg, Timothy Mark O'Shea, Yanxiang Cui, Z Hong Zhou, Michael V Sofroniew, Timothy J Deming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Triggered Inversion of Dual Responsive Diblock Copolypeptide Vesicles.Journal of the American Chemical Society · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Peptide-based coacervates in therapeutic applications.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yintao SunDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
Alexander L WollenbergDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
Timothy Mark O'SheaDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
Yanxiang CuiDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
Z Hong ZhouDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
Michael V SofroniewDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.ORCID 0000-0001-6075-0178
Timothy J DemingDepartment of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.ORCID 0000-0002-0594-5025

Funding

Injectable biomaterial depots to manipulate scar and foster axon growth after SCIR01NS084030 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOFRONIEW, MICHAEL V · 2014 to 2023
$3.0M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
NCRR NIH HHS S10 RR023057NINDS NIH HHS R01 NS084030
6 · The paper itself

Abstract

Synthetic diblock copolypeptides were designed to incorporate oppositely charged ionic segments that form β-sheet-structured hydrogel assemblies via polyion complexation when mixed in aqueous media. The observed chain conformation directed assembly was found to be required for efficient hydrogel formation and provided distinct and useful properties to these hydrogels, including self-healing after deformation, microporous architecture, and stability against dilution in aqueous media. While many promising self-assembled materials have been prepared using disordered or liquid coacervate polyion complex (PIC) assemblies, the use of ordered chain conformations in PIC assemblies to direct formation of new supramolecular morphologies is unprecedented. The promising attributes and unique features of the β-sheet-structured PIC hydrogels described here highlight the potential of harnessing conformational order derived from PIC assembly to create new supramolecular materials.

Indexed as

Molecular ConformationHydrogelsIonsPeptidesHydrogelsIonsPeptides

Identifiers

PMID28976744
PMCPMC6037417

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.