Evidence map›Paper›PMID 28976243›Full record

ArticleGut microbes2018

Colonic thioguanine pro-drug: Investigation of microbiome and novel host metabolism.

Timothy Florin, Ramya Movva, Jakob Begun, John Duley, Iulia Oancea, Páraic Ó Cuív

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Advances in Thiopurine Drug Delivery: The Current State-of-the-Art.European journal of drug metabolism and pharmacokinetics · 2021
    Review
  4. Mutations in a Membrane Permease orAntimicrobial agents and chemotherapy · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Timothy Florina Mater Research - University of Queensland, Translational Research Institute , Queensland , Australia.
Ramya Movvab Mater Research - University of Queensland , Queensland , Australia.
Jakob Beguna Mater Research - University of Queensland, Translational Research Institute , Queensland , Australia.
John Duleyc Pharmacy Australia Centre of Excellence , University of Queensland , Queensland , Australia.
Iulia Oanceaa Mater Research - University of Queensland, Translational Research Institute , Queensland , Australia.
Páraic Ó Cuívd Diamantina Institute - University of Queensland, Translational Research Institute , Queensland , Australia.
Mater Research · AUTranslational Research Institute · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiopurines are analogues of endogenous purines. They are pro-drugs which require the purine salvage pathway to convert them to the active drug nucleotides (TGN). These drugs are used to maintain clinical remission in patients with inflammatory bowel diseases. In our recent Gut paper, we showed that thioguanine worked quickly to improve colitis in the absence in the host animal of the key guanine salvage enzyme, hypoxanthine-guanine-phosphoribosyltransferase (HPRT). Current evidence favours the proposition that active drug delivery to the host lacking HPRT requires translocation of TGN-loaded bacteria across the inflamed mucosal barrier, and most likely delivery by phagocytosis. Alternatively, the efficacy of thioguanine in treating colitis could be mediated by modulation of the community of the microbiota in the intestine, or there are novel host pathways for conversion of the thioguanine pro-drug to TGN.

Indexed as

Administration, OralAdministration, RectalAnimalsAutophagyColitisColonDisease Models, AnimalGene Knockout TechniquesHost-Pathogen InteractionsHumansHypoxanthine PhosphoribosyltransferaseInflammatory Bowel DiseasesMiceMicrobiotaProdrugsThioguanineHypoxanthine PhosphoribosyltransferaseProdrugsThioguaninecolitisHarnessing microbial strategies for treatment of human diseasemicrobiomephagocytosispurine salvageRole of commensal flora in GI diseasesRole of gut microbiome in GI diseasethioguanine

Identifiers

PMID28976243
PMCPMC5989799
OpenAlexW2763128272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.