ArticleMolecular plant pathology2018
A mutation in an exoglucanase of Xanthomonas oryzae pv. oryzae, which confers an endo mode of activity, affects bacterial virulence, but not the induction of immune responses, in rice.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Guardians or Gateways? The Intricate Relationship Between Plant Cell Walls and Pathogenic Xanthomonas.Molecular plant pathology · 2026Review
- The dual role of Xanthomonas effector XccXynB in plant cell wall deconstruction and immunity activation.Plant cell reports · 2026Article
- Chiral dependence of multifunctional supramolecular materials in crop protection.Nature communications · 2025Article
- An Emerging Bacterial Leaf Disease in Rice Caused byMicroorganisms · 2025Article
- Searching for the Virulence-contributing Genes of thePathogens (Basel, Switzerland) · 2024Article
- Transcriptional regulator Sar regulates the multiple secretion systems in Xanthomonas oryzae.Molecular plant pathology · 2023Article
- Role of the FnIII domain associated with a cell wall-degrading enzyme cellobiosidase of Xanthomonas oryzae pv. oryzae.Molecular plant pathology · 2022Article
- Metagenomic mining and structure-function studies of a hyper-thermostable cellobiohydrolase from hot spring sediment.Communications biology · 2022Article
- An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.Science advances · 2022Article
- Arms and ammunitions: effectors at the interface of rice and it's pathogens and pests.Rice (New York, N.Y.) · 2021Review
- Repeated gain and loss of a single gene modulates the evolution of vascular plant pathogen lifestyles.Science advances · 2020Article
- Overexpression of OsPUB41, a Rice E3 ubiquitin ligase induced by cell wall degrading enzymes, enhances immune responses in Rice and Arabidopsis.BMC plant biology · 2019Article
- Xanthomonas oryzae pv. oryzae XopQ protein suppresses rice immune responses through interaction with two 14-3-3 proteins but its phospho-null mutant induces rice immune responses and interacts with another 14-3-3 protein.Molecular plant pathology · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial blight, a serious disease of rice. Xoo secretes a repertoire of cell wall-degrading enzymes, including cellulases, xylanases and pectinases, to degrade various polysaccharide components of the rice cell wall. A secreted Xoo cellulase, CbsA, is not only a key virulence factor of Xoo, but is also a potent inducer of innate immune responses of rice. In this study, we solved the crystal structure of the catalytic domain of the CbsA protein to a resolution of 1.86 Å. The core structure of CbsA shows a central distorted TIM barrel made up of eight β strands with N- and C-terminal loops enclosing the active site, which is a characteristic structural feature of an exoglucanase. The aspartic acid at the 131st position of CbsA was predicted to be important for catalysis and was therefore mutated to alanine to study its role in the catalysis and biological functions of CbsA. Intriguingly, the D131A CbsA mutant protein displayed the enzymatic activity of a typical endoglucanase. D131A CbsA was as proficient as wild-type (Wt) CbsA in inducing rice immune responses, but was deficient in virulence-promoting activity. This indicates that the specific exoglucanase activity of the Wt CbsA protein is required for this protein to promote the growth of Xoo in rice.
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